TABLE 1.Comparison of the characteristics of the in vivo and in vitro bursts of SON OT neurons from lactating rats in extracellular recordings
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Basal FR, Hz |
FR Prior to B:1 min |
FR Prior to B:20 s |
1st B Latency |
B FR, Hz |
Amp of B |
Duration of B, s |
Post-B Inhibition, s |
Peak FR, Hz |
Latency to PF, s |
Interval of Bs, min |
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In Vivo (n = 26) | |||||||||||
Value | 1.9 ± 0.15 | 2.5 ± 0.13† | 2.1 ± 0.15 | 16.6 ± 1.3 | 17.2 ± 0.71 | 72.7 ± 5.3 | 4.1 ± 0.15 | 15.6 ± 2.01 | 39.5 ± 2.54 | 0.41 ± 0.02 | 8.8 ± 0.51 |
Range | 0.3-3.3 | 1.2-4.2 | 1.4-4.3 | 8.1-35 | 11.2-31 | 52-158 | 3.1-5.9 | 4.5-56 | 19-89 | 0.15-0.62 | 4.5-15 |
Index of Dispersion | 0.29 | 0.2 | 0.3 | 2.71 | 0.76 | 10 | 0.12 | 2.46 | 4.27 | 0.024 | |
Correlation (r) | |||||||||||
Basal FR | 0.625** | 0.474* | -0.521** | 0.448* | 0.471* | 0.42* | -0.543** | 0.583** | -0.092 | -0.428* | |
1 min | 0.566** | -0.389* | 0.247 | 0.349 | 0.381 | -0.39* | 0.414* | 0.016 | -0.187 | ||
20 s | -0.3 | 0.423* | 0.513** | 0.461* | -0.322 | 0.471* | 0.041 | -0.387 | |||
In Vitro (n = 19) | |||||||||||
Value | 2.2 ± 0.40 | 3.3 ± 0.50 | 2.6 ± 0.60 | 12.6 ± 2.54 | 15.6 ± 1.79 | 48.4 ± 6.65** | 3.2 ± 0.31 | 4.3 ± 1.31** | 40.6 ± 2.91 | 0.23 ± 0.03** | 5.8 ± 0.97 |
Range | 0.1-5.2 | 0.2-6.9 | 0.1-5.2 | 1.6-34.6 | 6.6-39.7 | 20-102 | 1.0-6.9 | 0.5-21.3 | 14-65 | 0.05-0.51 | 2.2-15.2 |
Index of Dispersion | 1.36 | 1.45 | 2.64 | 9.73 | 3.89 | 17.4 | 0.57 | 7.49 | 3.96 | 0.08 | 3.09 |
Correlation (r) | |||||||||||
Basal FR | 0.932** | 0.687** | -0.37 | 0.044 | 0.358 | 0.368 | -0.151 | 0.259 | -0.039 | -0.082 | |
1 min | 0.701** | -0.465* | 0.202 | 0.401 | 0.27 | -0.177 | 0.324 | 0.114 | -0.196 | ||
20 s |
-0.444 |
0.098 |
0.511* |
0.546* |
-0.256 |
0.319 |
0.006 |
-0.366 |
Value is expressed as mean ± SE; SON, supraoptic nucleus; OT, oxytocin; FR, firing rate; B, burst; Amp (amplitude) of B: spikes/burst;
PF, peak FR. *P < 0.05 and **P < 0.01 compared with the in vivo bursts by Student's t-test, or other parameters with the basal activity in correlation analysis; †P < 0.05 by comparison between basal firing rates of 20 s and 1 min preceding the burst.