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Article: Effects of familial hemiplegic migraine type 1 mutation T666M on voltage-gated calcium channel activities in trigeminal ganglion neurons.

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Tao J; Liu P; Xiao Z; Zhao H; Gerber BR; Cao YQ
J. Neurophysiol., 2012


Table 3.

Voltage-dependence of activation of total VGCC currents in subpopulation of TG neurons

Small IB4− TG Neurons (22.3 ± 0.8 pF) Small IB4+ TG Neurons (24.2 ± 2.2 pF) Medium-sized TG Neurons (34.1 ± 3.3 pF)
V50,tail, mV k, mV/e-fold change n V50,tail, mV k, mV/e-fold change n V50,tail, mV k, mV/e-fold change n
hWT −17.0 ± 1.1 5.9 ± 2.4 8 −13.6 ± 2.2 6.4 ± 1.3 6 −13.2 ± 2.5 7.4 ± 1.8 8
T666M −25.3 ± 1.7* 5.4 ± 0.9 8 −13.2 ± 2.7 8.5 ± 1.2 5 −14.3 ± 1.3 6.8 ± 0.8 11

  • Values are means ± SE; n, number of neurons.

  • ↵* P < 0.05, t-test.


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