DA Neurons | GABA Neurons | Significance | |
---|---|---|---|
Peak Na+ conductance density, pS μm2 | 24.5 ± 1.7 (15) | 41.6 ± 4.6 (17) | P < 0.001 |
Vmid of activation, mV | −9.6 ± 1.9 (8) | −12.6 ± 1.4 (7) | — |
k of activation, mV | 12.0 ± 0.7 | 11.0 ± 0.5 | — |
Vmid of inactivation, mV | −48.9 ± 1.4 (11) | −56.1 ± 1.8 (15) | P < 0.01 |
k of inactivation, mV | −10.5 ± 0.7 | −9.9 ± 0.6 | — |
Activation time constant τm, μs | 474 ± 84 s at − 30 mV (9) | 246 ± 48 s at − 30 mV (10) | P < 0.05 |
Deactivation time constant τd, μs | 161 ± 20 s at −40 mV (5) | 160 ± 11 s at −40 mV (9) | — |
Inactivation time constant τh, ms | 1.8 ± 0.2 s at − 20 mV (6) | 1.3 ± 0.2 s at −20 mV (6) | — |
τ of onset of inactivation at −55 mV, ms | 45.0 ± 8.0 (6) (50 ± 2%) | 25.8 ± 4.0 (7) (43 ± 6%) | — |
τ of recovery from inactivation at −120 mV, ms | 1.4 ± 0.1 (77 ± 3%) | 1.2 ± 0.2 (73 ± 2%) | — |
84.8 ± 29.3 (9) | 107.6 ± 21.9 (7) | — |
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Numerical values are given as means ± SE, and total number of nucleated patches in parentheses. The values given in parentheses for the time constants of recovery from inactivation indicate the amplitude contribution of the fast recovery (expressed as percentage). The values given in parentheses for the onset of inactivation at −55 mV indicate the amplitude proportion of the remaining Na+ current amplitude at the end of the 190 ms pulse. Statistical significance is given by P value and − represent (P > 0.05).