Table 2
Rise and decay time constants of the NMDAR currents in CA1 pyramidal cells and interneurons
| Low-Mg2+ ACSF | D-serine | |||||
|---|---|---|---|---|---|---|
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| Inactivation | Inactivation | |||||
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| Cell types | τact (ms) | τf (ms) | τs (ms) | τact (ms) | τf (ms) | τs (ms) |
| Pyramidal cells | 13.18 ± 2.64 n = 17 | 56.62 ± 7.44 n = 17 | — | 13.28 ± 2.68 n = 17 | 71.52 ± 6.46 n = 17 | — |
| Interneurons | 11.46 ± 2.49 n = 12 | 36.83 ± 2.76 n = 12 | 242.4 ± 33.79 n = 12 | 12.94 ± 1.88 n = 12 | 55.78 ± 5.38 n = 12 | 244.0 ± 31.35 n = 12 |
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Values are means ± s.e.m. Low-Mg2+ ACSF: electrically evoked NMDAR currents were recorded in a low-Mg2+ ACSF (0.1 mM) in the presence of NBQX (20 μm), picrotoxin (50 μm), CGP 52432 (10 μm) and strychnine (0.5 μM). The fast and the slow decay components are designated by τf, and τs, respectively. D-serine: the ACSF was the same as in Low-Mg2+ ACSF plus D-serine (10 μm). In PCs and Ints, the τf was significantly increased by the application of D-serine (P < 0.05).