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Article: Similar electrophysiological changes in axotomized and neighboring intact dorsal root ganglion neurons.

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Ma C; Shu Y; Zheng Z; Chen Y; Yao H; Greenquist KW; White FA; LaMotte RH
J. Neurophysiol., 2003


Table 1.

Electrophysiological properties of DRG neurons from axotomized and intact ganglia after SNL

Size Category Large Medium Small
Treatment Sham DRGL4 DRGL5 Sham DRGL4 DRGL5 Sham DRGL4 DRGL5
Cell size, um 58.7  ±  1.7 58.9  ±  1.3 57.9  ±  0.9 38.1  ±  0.7 37.6  ±  0.7 38.4  ±  0.6 25.5  ±  0.6 25.3  ±  0.6 26.7  ±  0.6
n 44 44 96 40 34 47 72 74 39
RMP, mV −60.1  ±  1.0 −60.3  ±  1.1 −57.1  ±  0.6 −56.6  ±  1.3 −54.1  ±  1.2 −53.5  ±  1.0 −52.3  ±  0.9 −51.4  ±  0.9 −50.3  ±  1.2
n 44 44 96* 40 34 47 72 74 39
Rin, Mohm 20.2  ±  1.7 27.4  ±  3.0 31.7  ±  2.1 29.9  ±  2.7 27.5  ±  2.9 38.5  ±  3.7 39.7  ±  2.8 44.1  ±  3.9 50.2  ±  4.6
n 36 29* 711-160 33 31 41 66 63 36
Curr. thre., nA 1.55  ±  0.22 1.16  ±  0.16 0.72  ±  0.05 0.88  ±  0.12 0.84  ±  0.09 0.52  ±  0.04 0.62  ±  0.05 0.64  ±  0.06 0.62  ±  0.06
n 31 21* 771-160 31 31 441-160 58 53 37
Vol. thre., mV −39.9  ±  1.3 −45.9  ±  1.6 −45.9  ±  0.9 −32.4  ±  2.0 −33.8  ±  3.0 −40.5  ±  2.0 −21.4  ±  1.2 −23.6  ±  1.8 −34.4  ±  2.2
n 33 241-160 551-160 26 22 31* 50 41 211-160 1-164
APD50, ms 0.49  ±  0.06 0.67  ±  0.10 0.99  ±  0.06 0.96  ±  0.08 1.56  ±  0.22 1.46  ±  0.12 2.73  ±  0.27 2.78  ±  0.18 2.80  ±  0.25
n 23 23* 581-160 25 22* 27* 32 40 21
dV/dt r., mV/ms 296  ±  27.3 248  ±  28.4 199  ±  10.3 202  ±  17.3 138  ±  12.2 145  ±  9.0 109  ±  7.5 96.7  ±  7.3 99.1  ±  10.1
n 23 23 581-160 26 22* 27* 32 40 21
dV/dt f., mV/ms −181  ±  18.6 −133  ±  11.4 −88.5  ±  5.6 −112  ±  12.0 −74.3  ±  7.8 −63.2  ±  4.1 −60.9  ±  4.4 −48.1  ±  4.0 −41.1  ±  2.6
n 23 231-160 581-160 26 22* 27* 32 40* 211-160
AHP50, ms 3.23  ±  0.35 4.11  ±  0.68 3.82  ±  0.36 4.21  ±  0.72 5.54  ±  0.83 5.03  ±  0.53 8.71  ±  1.12 7.22  ±  0.55 6.31  ±  0.54
n 23 23 50 23 21 25 31 41 18
AHP amp., mV −9.9  ±  0.6 −9.7  ±  0.5 −7.0  ±  0.4 −10.8  ±  1.0 −12.1  ±  1.1 −8.78  ±  0.8 −10.5  ±  0.9 −11.1  ±  0.7 −11.9  ±  0.8
n 23 23 511-160 1-164 23 21 25 .31 41 18
  • Values are means ± SE, and n = sample size; SNL: L5 spinal nerve ligation and transection; DRG L4 and L5: intact (L4) and axotomized (L5) ganglia from SNL rats, Sham: ganglion from Sham-operated rats; Cell size: mean diameter of neuron; RMP: resting membrane potential; Curr. thre.: current threshold; Vol. thre.: voltage threshold; APD50: action potential (AP) duration at half width, dV/dt r.: maximum rising rate of AP; dV/dt f.: maximum falling rate of AP; AHP50: afterhyperpolarization duration at half width; AHP amp.: amplitude of afterhyperpolarization.

  • *P < 0.05,

  • F1-160P < 0.01, DRG L4 or DRG L5 vs. Sham;

  • P < 0.05,

  • F1-164P < 0.01, DRG L5 vs. DRG L4.


Report miscurated data

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dorsal root ganglion cell resting membrane potential (mV) -60.1 ± 1.0 -60.1 (mV) Data Table
Dorsal root ganglion cell input resistance (Mohm) 20.2 ± 1.7 20.2 (MΩ) Data Table