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Article: Mechanisms of dopamine activation of fast-spiking interneurons that exert inhibition in rat prefrontal cortex.

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Gorelova N; Seamans JK; Yang CR
J. Neurophysiol., 2002


Table 2.

Effects of DA and D1, D2 receptors agonists on spike properties of FS interneurons

Control DA (n = 8) Control SKF81297 (n = 6) Control Quinpirole (n = 7)
Spike amplitude (mV) 88  ±  3.8 88  ±  4.1 NA NA NA NA
Spike width (ms) 0.54  ±  0.06 0.54  ±  0.05 NA NA NA NA
Spike threshold (mV) −40.5  ±  4.5 −43.3  ±  4† −40.9  ±  3 −43  ±  2.5* −41.3  ±  4.1 −40.8  ±  4
AHP (mV) 18.2  ±  4.8 17.8  ±  3.4 18.9  ±  2.8 19.1  ±  2.7 17.9  ±  2.5 17.8  ±  2.7
First spike latency (ms) 20.9  ±  3.2 16.3  ±  1.9* 20.4  ±  1.9 15.4  ±  2† 18.4  ±  4.2 18.7  ±  3.5
First interspike interval (ms) 24.7  ±  5.7 21  ±  4.2* 24.1  ±  5.5 19.8  ±  4* 25.6  ±  4.8 27.4  ±  6.2

  • The first spike latency value taken for each cell was measured from spikes evoked by minimum depolarizing current intensity that induced one or more spikes in the control. The first inter-spike interval was measured from spikes evoked by the minimum current intensity that evoked a train of non-accommodating spikes in control. Changes in spike responses to the same current intensity pulse subsequent to drug application were then analyzed. The membrane potential was held via DC current injection at the same levels in the control and in the drug. NA, not analyzed.

  • ↵*  P < 0.01.

  • ↵†  P< 0.005.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex basket cell Prefrontal cortex fast spiking interneuron spike amplitude (mV) 88.0 ± 3.8 (8) 88.0 (mV) Data Table
Neocortex basket cell Prefrontal cortex fast spiking interneuron spike half-width (ms) 0.54 ± 0.06 (8) 0.54 (ms) Data Table
Neocortex basket cell Prefrontal cortex fast spiking interneuron spike threshold (mV) -40.5 ± 4.5 (8) -40.5 (mV) Data Table
Neocortex basket cell Prefrontal cortex fast spiking interneuron AHP amplitude (mV) 18.2 ± 4.8 (8) 18.2 (mV) Data Table
Neocortex basket cell Prefrontal cortex fast spiking interneuron first spike latency (ms) 20.9 ± 3.2 (8) 20.9 (ms) Data Table