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Article: Carbenoxolone blockade of neuronal network activity in culture is not mediated by an action on gap junctions.

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Rouach N; Segal M; Koulakoff A; Giaume C; Avignone E
J. Physiol. (Lond.), 2003


Table 2

Characteristics of neuronal bicuculline-induced discharges in co-cultures

Control 100 μm CBX Wash Control 100 μm GZA
Frequency of events (min−1) 2.1 ± 0.2(8) 0.5 ± 0.2**(8) 1.4 ± 0.3(5) 2.0 ± 0.4(4) 1.7 ± 0.2(4)
Baseline (F0) (a.u.) 890 ± 109(8) 954 ± 105(8) 810 ± 101(5) 875 ± 77(4) 982 ± 109(4)
Peak normalised amplitude (ΔF/F0) 126 ± 25(8) 81 ± 28*(6) 119 ± 37(5) 191 ± 33(4) 160 ± 80(4)
Decay time (s) 4.87 ± 0.52(7) 3.34 ± 0.35*(6) 4.22 ± 0.21(4) 5.45 ± 0.89(4) 5.06 ± 0.3(4)
Coefficient of correlation 0.96 ± 0.01(8) 0.66 ± 0.09**(8) 0.73 ± 0.1(5) 0.98 ± 0.01(4) 0.98 ± 0.01(4)
  • Data are expressed as mean ±s.e.m. and are sampled from neurons recorded before (control), after perfusion with carbenoxolone (CBX, 100 μm, 10 min) and wash or after glycyrrhizic acid(GZA, 100 μm, 10 min). ANOVA followed by post hoc Bonferroni's multiple comparison (CBX) or Student's unpaired t test (GZA) were applied for statistical analysis

  • * P < 0.05,

  • ** P < 0.01.

  • Numbers in parentheses are the number of independent experiments.


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