AboutNeuron TypesElectrophysiology PropertiesArticlesFAQsData/APIGet Involved

Article: The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons?

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Margolis EB; Lock H; Hjelmstad GO; Fields HL
J. Physiol. (Lond.), 2006


Table 2. Among Ih(+) neurons, there are no differences between the basic membrane properties of DA and non-DA VTA neurons

Vmi (mV) AP threshold (mV) AP height, threshold to peak (mV) AP height, peak to trough (mV) Fast afterhyper- polarization, magnitude from peak (mV) Afterhyper- polarization, minimum (mV)
*Ih(−) neurons differ from TH(+) neurons, P < 0.05. **Confirmed TH(−) neurons only are included in this measure. Vmi, initial membrane potential; AP, action potential.
Ih(+) TH(+) −44 ± 1 −24 ± 2 60 ± 3 89 ± 3 92 ± 5 −53 ± 3
n = 50 n = 35 n = 23 n = 35
Ih(+) TH(−) −46 ± 1 −28 ± 2 56 ± 3 81 ± 4 78 ± 6 −53 ± 2
n = 44 n = 33 n = 22 n = 33
Ih(−) −45 ± 2 −31.1 ± 0.9* 57 ± 4 85 ± 5 89 ± 5 −59 ± 2
n = 16** n = 26 n = 21 n = 26
P = 0.57 0.047 0.59 0.34 0.14 0.15

Report miscurated data

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Ventral tegmental area dopamine neuron Ventral Tegmental Area tyrosine hydroxylase immunoreactive Ih positive dopaminergic neuron resting membrane potential (mV) -44.0 ± 1.0 (35) -44.0 (mV) Data Table
Ventral tegmental area dopamine neuron Ventral Tegmental Area tyrosine hydroxylase immunoreactive Ih positive dopaminergic neuron spike threshold (mV) -24.0 ± 2.0 (35) -24.0 (mV) Data Table
Ventral tegmental area dopamine neuron Ventral Tegmental Area tyrosine hydroxylase immunoreactive Ih positive dopaminergic neuron spike amplitude (mV) 60.0 ± 3.0 (35) 60.0 (mV) Data Table
Ventral tegmental area dopamine neuron Ventral Tegmental Area tyrosine hydroxylase immunoreactive Ih positive dopaminergic neuron spike amplitude from trough (mV) 89.0 ± 3.0 (35) 89.0 (mV) Data Table
Ventral tegmental area dopamine neuron Ventral Tegmental Area tyrosine hydroxylase immunoreactive Ih positive dopaminergic neuron fast AHP amplitude (mV) 92.0 ± 5.0 (35) -- Data Table
Ventral tegmental area dopamine neuron Ventral Tegmental Area tyrosine hydroxylase immunoreactive Ih positive dopaminergic neuron AHP voltage (mV) -53.0 ± 3.0 (35) -53.0 (mV) Data Table
Other Ventral Tegmental Area non-tyrosine hydroxylase immunoreactive Ih positive neuron resting membrane potential (mV) -46.0 ± 1.0 (33) -46.0 (mV) Data Table
Other Ventral Tegmental Area non-tyrosine hydroxylase immunoreactive Ih positive neuron spike threshold (mV) -28.0 ± 2.0 (33) -28.0 (mV) Data Table
Other Ventral Tegmental Area non-tyrosine hydroxylase immunoreactive Ih positive neuron spike amplitude (mV) 56.0 ± 3.0 (33) 56.0 (mV) Data Table
Other Ventral Tegmental Area non-tyrosine hydroxylase immunoreactive Ih positive neuron spike amplitude from trough (mV) 81.0 ± 4.0 (33) 81.0 (mV) Data Table
Other Ventral Tegmental Area non-tyrosine hydroxylase immunoreactive Ih positive neuron fast AHP amplitude (mV) 78.0 ± 6.0 (33) -- Data Table
Other Ventral Tegmental Area non-tyrosine hydroxylase immunoreactive Ih positive neuron AHP voltage (mV) -53.0 ± 2.0 (33) -53.0 (mV) Data Table
Other Ventral Tegmental Area non-tyrosine hydroxylase immunoreactive Ih negative neuron resting membrane potential (mV) -45.0 ± 2.0 (26) -45.0 (mV) Data Table
Other Ventral Tegmental Area non-tyrosine hydroxylase immunoreactive Ih negative neuron spike threshold (mV) -31.1 ± 0.9 (26) -31.1 (mV) Data Table
Other Ventral Tegmental Area non-tyrosine hydroxylase immunoreactive Ih negative neuron spike amplitude (mV) 57.0 ± 4.0 (26) 57.0 (mV) Data Table
Other Ventral Tegmental Area non-tyrosine hydroxylase immunoreactive Ih negative neuron spike amplitude from trough (mV) 85.0 ± 5.0 (26) 85.0 (mV) Data Table
Other Ventral Tegmental Area non-tyrosine hydroxylase immunoreactive Ih negative neuron fast AHP amplitude (mV) 89.0 ± 5.0 (26) -- Data Table
Other Ventral Tegmental Area non-tyrosine hydroxylase immunoreactive Ih negative neuron AHP voltage (mV) -59.0 ± 2.0 (26) -59.0 (mV) Data Table