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Article: M1 and M4 receptors modulate hippocampal pyramidal neurons.

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Dasari S; Gulledge AT
J. Neurophysiol., 2011


Table 2.

Comparison of tonic cholinergic responses in hippocampal CA1 pyramidal neurons expressing different mAChR subtypes

Genotype Layer n ΔRMP, mV ΔAHP Amplitude, mV ΔADP Amplitude, mV
Wild-type (WT) CA1 13 +3.6 ± 0.5 −1.8 ± 0.4 +1.9 ± 0.2
M3/M5 DKO CA1 12 +2.2 ± 0.6 −2.5 ± 0.6 +2.6 ± 0.6
M1 KO CA1 12 +2.5 ± 0.9 0.0 ± 0.4* +0.2 ± 0.4*
M1/M3 DKO CA1 7 −0.2 ± 0.6* 0.0 ± 0.2* +0.1 ± 0.3*

  • Values are means ± SE. Cholinergic responses were evoked by bath-applied carbachol (10 μM for 5 min) in CA1 pyramidal neurons. Listed are changes in RMP and AHP and ADP amplitudes measured at the end of carbachol treatment and relative to values measured in baseline conditions. Numbers in boldface type indicate P < 0.05 for carbachol-induced effects within individual cell types (repeated-measures ANOVA with post-tests: baseline, carbachol, and wash). Asterisks indicate P < 0.01 when compared with results in wild-type neurons (one-way ANOVA with post-tests).


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