Table 1.
Hypoglossal motoneuron properties
| mSOD1WT | hSOD1G93A | |
|---|---|---|
| Cell properties | ||
| Resting membrane potential (mV) | −59 ± 5 | −61 ± 6 |
| Input resistance (MΩ) | 111 ± 18 | 106 ± 18 |
| Action potential properties | ||
| Threshold (mV above resting MP) | 21 ± 3 | 22 ± 3 |
| Amplitude (mV above threshold MP) | 69 ± 4 | 87 ± 4** |
| Maximum rate of AP rise (mV/ms) | 189 ± 32 | 232 ± 56 |
| Duration (ms) | 3.7 ± 0.5 | 3.0 ± 0.4 |
| Half-width duration (ms) | 1.6 ± 0.2 | 1.4 ± 0.2 |
| Afterhyperpolarization amplitude (mV below threshold MP) | −27 ± 2 | −29 ± 3 |
| Number of cells | 7 | 7 |
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Averaged cell properties and AP properties (analyzed from single APs) are shown for mSOD1WT and hSOD1G93A HMs (P6–P8). In this table and Table 2, resting membrane potential has been corrected for a calculated junction potential of 13 mV (JPCalc, Clampfit). AP threshold is relative to resting membrane for each HM recorded; AP and afterhyperpolarization amplitude are relative to AP threshold potential for each HM recorded. Note that only the AP amplitude is significantly increased in hSOD1G93A HMs. Statistical significance (Student's unpaired t test) is indicated. Data are mean ± SEM.