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Article: Intracellular correlates of spatial memory acquisition in hippocampal slices: long-term disinhibition of CA1 pyramidal cells.

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Gusev PA; Alkon DL
J. Neurophysiol., 2001


Table 1.

PSP parameters of CA1 pyramidal cells as functions of training procedures

WMT1 SW1 Naı̈ve WMT3 SW3
IPSPs peak at ≤70 ms
Maximum peak IPSP, mV −10.3 ± 0.4 −9.2 ± 0.3 −10 ± 0.5 −8.3 ± 0.51-160 † 1-153 −9.5 ± 0.5
 n 43 39 44 50 48
Time to IPSP peak, ms 34 ± 1.2 34 ± 1.1 30.8 ± 1.2 35.7 ± 1.71-160 ‡ 30.8 ± 1.3
Maximum −9.7 ± 0.4 −8.7 ± 0.2 −9.3 ± 0.5 −7.5 ± 0.51-160 1-162 −8.5 ± 0.41-153
IPSP at 40 ms, mV
 Maximum −5.6 ± 0.3* −5.2 ± 0.3 −4.6 ± 0.3 −2.8 ± 0.31-168 1-162 −3.4 ± 0.31-160 1-162
IPSP at 200 ms, mV
 Maximum −2.9 ± 0.21-160 −2.7 ± 0.2* −2.2 ± 0.2 −1.3 ± 0.21-165 1-162 −1.5 ± 0.11-160 1-162
IPSP at 350 ms, mV
Maximum peak EPSP, mV 6.5 ± 0.3* 6.3 ± 0.31-160 7.6 ± 0.4 8.5 ± 0.31-162 7.8 ± 0.31-153
Initial rising 3.9 ± 0.2 3.7 ± 0.2 4.3 ± 0.2 3.9 ± 0.2 3.9 ± 0.2
EPSP slope, mV/ms
Time to EPSP peak, ms 5.1 ± 0.2 5 ± 0.1 5 ± 0.1 5.8 ± 0.2* † 1-153 5.2 ± 0.2
E IPSP at 40 ms −76.7 ± 1.3 −81 ± 0.7 −79.3 ± 0.8 −77.7 ± 1.1 −80.2 ± 1
 n 13 17 42 45 44
E IPSP at 150 ms −94 ± 3.3 −100.8 ± 1.9 −100.1 ± 1.5 −97.8 ± 1.6 −102.1 ± 1.5
 n 13 17 41 42 43
g IPSP at 40 ms 25 ± 3.7 23 ± 2.9 25.9 ± 2.2 22 ± 2.1 25.8 ± 2.7
 n 12 17 43 45 44
g IPSP at 150 ms 5.3 ± 0.5 5.6 ± 0.8 4.2 ± 0.4 3.1 ± 0.41-162 3.5 ± 0.41-162
 n 12 17 42 42 43
V m, mV 63.7 ± 0.3 63.2 ± 0.3* 64.3 ± 0.4 64.8 ± 0.31-162 64.7 ± 0.31-160 1-173
 n 43 39 44 50 48

  • Isochronal analysis of the complex postsynaptic potentials (PSPs) revealed disinhibition of the CA1 pryamidal cells (PCs) that was correlated with spatial memory formation. The learning-specific disinhibition was accompanied by the reduced peak inhibitory PSP (IPSP) amplitudes and longer times to the IPSP and excitatory PSP (EPSP) peaks (underlined). In general, the SW3 cells recorded after 3 days of swimming without platform had a mean V m slightly more hyperpolarized as compared to the naı̈ve, SW1, WMT1 groups. The WMT3 cells had a mean V m somewhat more hyperpolarized as compared to SW1 and WMT1 but not to the naı̈ve neurons. Data presented as means ± SE. WMT1 and WMT3, groups water-maze trained for 1 or 3 days, respectively; SW1 and SW3, control groups that swam for 1 or 3 days.

  • ↵*  P < 0.05,

  • ↵F1-160  P < 0.01,

  • ↵F1-165  P < 0.0001,

  • ↵F1-168  P < 0.0001 significantly different from naı̈ve control.

  • ↵†  P < 0.05,

  • ↵‡  P < 0.01 significantly different from parallel swim control.

  • ↵F1-153  P < 0.01,

  • ↵F1-162  P < 0.001,

  • ↵F1-173  P < 0.0001 significantly different from the WMT1 and (or) SW1 group, Fisher's post hoc test.


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