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Article: Intracellular correlates of spatial memory acquisition in hippocampal slices: long-term disinhibition of CA1 pyramidal cells.

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Gusev PA; Alkon DL
J. Neurophysiol., 2001


Table 3.

Intrinsic membrane characteristics of pyramidal neurons without learning-specific changes after water-maze training

WMT1 SW1 Naı̈ve WMT3 SW3
1-spike sAHP amplitude, mV −1.25 ± 0.11 −1.16 ± 0.11 −1.07 ± 0.1 −1.37 ± 0.08 −1.24 ± 0.08
 n 23 35 50 59 51
Latency of 1-spike sAHP peak, ms 273 ± 20.3 283 ± 25.5 250 ± 23.8 261 ± 14.9 254 ± 16
I, nA to evoke 4 spikes 0.32 ± 0.023-150 0.31 ± 0.023-160 0.38 ± 0.02 0.45 ± 0.033-152 0.45 ± 0.033-152
 n 64 65 62 64 63
Postburst sAHP amplitude, mV −6 ± 0.3 −6.3 ± 0.3 −6.8 ± 0.4 −7.7 ± 0.43-152 −7.4 ± 0.33-151
Time to peak 4-spike sAHP, ms 284 ± 8.9 287 ± 8.7 285 ± 9.8 278 ± 8.7 292 ± 8.3
Decay time to Formula of sAHP peak, ms 1,514 ± 51.7 1,561 ± 53.3 1,516 ± 63.1 1,427 ± 55.7 1,480 ± 63.5
Total time of interspike intervals in 4-spike burst, ms 68.7 ± 1.9 65 ± 1.6 67.3 ± 1.1 66.3 ± 1.2 67.7 ± 1.3
Spike height, mV 78.1 ± 0.7 77.6 ± 0.6 77.3 ± 0.6 81.6 ± 0.83-153 3-170 80.1 ± 0.63-160 3-152
Spike width, ms 1.42 ± 0.2 1.36 ± 0.1 1.43 ± 0.02 1.43 ± 0.02 1.48 ± 0.02
Number of spikes per 800-ms 5.5 ± 0.2 5.5 ± 0.2 5.7 ± 0.3 5.4 ± 0.2 5.5 ± 0.2
 n 60 63 62 62 62
ΔV m below 1-st spike threshold in 4-spike burst 8.4 ± 0.3 8.2 ± 0.3 8.7 ± 0.3 8.8 ± 0.3 8.4 ± 0.3
Membrane potential, mV −64.4 ± 0.3 −64.2 ± 0.3 −64.4 ± 0.3 −64.8 ± 0.26 −64.4 ± 0.28
Resting V m before electrode was withdrawn, mV −61.7 ± 0.6 −61.4 ± 0.6 −61.3 ± 0.6 −63.5 ± 0.7 −62.7 ± 0.6

  • There was no learning-specific modification of intrinsic membrane excitability following water-maze training in CA1 pyramidal cells. sAHP, slow after hyperpolarization.

  • ↵F3-150  P < 0.05,

  • ↵F3-160  P < 0.01,

  • F3-165  P < 0.0001 significantly different from naı̈ve control;

  • ↵F3-151  P < 0.05,

  • ↵F3-152  P < 0.01,

  • ↵F3-170  P < 0.001 significantly different from the SW1 and WMT1 cells, Fisher's post hoc test;

  • ↵F3-153  P < 0.001 significantly different from the naive cells, Scheffe's post hoc test.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell slow AHP amplitude (mV) -6.8 ± 0.4 (62) 6.8 (mV) Data Table
Hippocampus CA1 pyramidal cell slow AHP duration (ms) 285.0 ± 9.8 (62) 285.0 (ms) Data Table
Hippocampus CA1 pyramidal cell spike amplitude (mV) 77.3 ± 0.6 (62) 77.3 (mV) Data Table
Hippocampus CA1 pyramidal cell spike half-width (ms) 1.43 ± 0.02 (62) 1.43 (ms) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -64.4 ± 0.3 (62) -64.4 (mV) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -61.3 ± 0.6 (62) -61.3 (mV) Data Table