Table 2. Parameters of the resting spontaneous activity of MVN neurons recorded in juvenile mice using EGTA-containing intracellular solution
| Parameters | KCNE1+/− heterozygous mutant mice | KCNE1−/− homozygous mutant mice | ||||||
|---|---|---|---|---|---|---|---|---|
| All neurons | Type A | Type B+ | Type B0 | All neurons | Type A | Type B+ | Type B0 | |
| *Significant differences between the whole sets of neurons recorded on KCNE1−/− versus KCNE1+/− mutant mice. §Significant differences between KCNE1−/− and KCNE1+/− mutant mice for specific types of MVN neurons. #Significant differences between type A neurons and at least 1 of type B+ and type B0 neurons in either KCNE1−/− or KCNE1+/− mice. †Significant differences between type B+ and type B0 neurons in either KCNE1−/− or KCNE1+/− mice. All numerical values that take part in significant differences are shown in bold. | ||||||||
| Number and proportion | 54 (100%) | 9 (17%) | 26 (48%) | 19 (35%) | 30 (100%) | 3 (10%) | 13 (43%) | 14 (47%) |
| Membrane potential (mV) | −61.5 ± 4.5 | −61.3 ± 4.1 | −62.4 ± 5.2 † | −60.3 ± 3.7 † | −60.9 ± 3.9 | −62.8 ± 4.0 | −60.5 ± 4.1 | −60.8 ± 3.8 |
| Spike threshold (mV) | −47.3 ± 6.5 | −45.1 ± 5.2 | −49.0 ± 6.1 | −46.0 ± 7.2 | −46.9 ± 5.7 | −47.4 ± 1.7 | −47.6 ± 7.0 | −46.1 ± 5.0 |
| Firing rate (spikes s−1) | 8.2 ± 5.7 * | 5.0 ± 2.8 # | 9.8 ± 6.3 § # | 7.5 ± 5.2 § # | 13.3 ± 10.8 * | 6.7 ± 1.6 | 17.9 ± 14.8 § | 10.5 ± 4.1 § |
| Coefficient of variation | 0.18 ± 0.15 * | 0.25 ± 0.12 # | 0.14 ± 0.11 # | 0.20 ± 0.20 | 0.11 ± 0.09 * | 0.14 ± 0.09 | 0.12 ± 0.11 | 0.09 ± 0.08 |
| AHPR (mV s−1) | 32 ± 46 | 117 ± 24 # | 9 ± 20 # | 22 ± 31 # | 27 ± 49 | 128 ± 33 # | 28 ± 47 # | 4 ± 10 # |
| dAHP (V s−1) | 0.24 ± 0.35 | 0.00 ± 0.00 # | 0.50 ± 0.36 # † | 0.00 ± 0.00 † | 0.42 ± 0.99 | 0.00 ± 0.00 # | 0.97 ± 1.34 # † | 0.00 ± 0.00 † |
| Spike width (ms) | 1.83 ± 0.64 | 1.88 ± 0.33 # | 1.45 ± 0.28 § # † | 2.31 ± 0.77 § † | 1.52 ± 0.61 | 1.67 ± 0.45 # | 1.21 ± 0.57 § # † | 1.78 ± 0.58 §† |
| Spike height (mV) | 63.5 ± 9.6 * | 63.3 ± 5.3 | 65.9 ± 9.9 § | 60.4 ± 10.3 | 59.3 ± 9.9 * | 66.4 ± 2.3 | 57.2 ± 8.6 § # | 59.7 ± 11.6 |
| AHP (mV) | 20.8 ± 5.7 | 24.8 ± 3.0 # | 19.5 ± 5.1 # | 20.6 ± 6.6 | 20.3 ± 4.9 | 25.6 ± 4.5 | 19.0 ± 5.5 | 20.3 ± 3.8 |
| Concavity (mV) | −0.78 ± 1.30 * | −1.69 ± 1.09 # | −0.66 ± 1.49 # | −0.52 ± 0.93 § # | −0.35 ± 0.78 * | −1.42 ± 0.81 # | −0.49 ± 0.96 # † | 0.00 ± 0.00 § #† |
| Convexity (mV) | 1.00 ± 0.76 | 0.55 ± 0.28 # | 1.18 ± 0.86 # | 0.97 ± 0.69 § | 1.17 ± 0.72 | 0.58 ± 0.41 # | 1.08 ± 0.91 | 1.39 ± 0.48 § # |