Table 3. Parameters of the resting spontaneous activity of MVN neurons recorded in juvenile mice using BAPTA-containing intracellular solution
| Parameters | KCNE1+/− heterozygous mutant mice | KCNE1−/− homozygous mutant mice | ||||||
|---|---|---|---|---|---|---|---|---|
| All neurons | Type A | Type B+ | Type B0 | All neurons | Type A | Type B+ | Type B0 | |
| *Significant differences between the whole sets of neurons recorded on KCNE1−/− versus KCNE1+/− mutant mice. §Significant differences between KCNE1−/− and KCNE1+/− mutant mice for specific types of MVN neurons. #Significant differences between type A neurons and at least 1 of type B+ and type B0 neurons in either KCNE1−/− or KCNE1+/− mice. †Significant differences between type B+ and type B0 neurons in either KCNE1−/− or KCNE1+/− mice. All numerical values that take part in significant differences are shown in bold. | ||||||||
| Number and proportion | 19 (100%) | 8 (42%) | 6 (32%) | 5 (26%) | 22 (100%) | 3 (14%) | 12 (55%) | 7 (32%) |
| Membrane potential (mV) | −61.2 ± 3.3 | −60.5 ± 1.9 § | −61.9 ± 4.8 | −61.3 ± 3.3 | −59.6 ± 4.5 | −54.7 ± 1.7 § # | −60.1 ± 2.1 # | −60.9 ± 6.8 |
| Spike threshold (mV) | −46.0 ± 4.7 | −44.9 ± 3.7 | −48.7 ± 4.5 | −44.3 ± 5.4 | −47.7 ± 7.0 | −42.6 ± 1.6 # | −47.5 ± 6.9 | −50.4 ± 7.9 # |
| Firing rate (spikes s−1) | 6.5 ± 4.7 | 5.0 ± 2.6 | 7.2 ± 6.4 | 7.4 ± 5.0 | 8.2 ± 6.3 | 8.8 ± 8.4 | 8.3 ± 7.1 | 7.9 ± 4.7 |
| Coefficient of variation | 0.16 ± 0.10 | 0.17 ± 0.10 | 0.19 ± 0.11 | 0.13 ± 0.09 | 0.22 ± 0.21 | 0.15 ± 0.12 | 0.25 ± 0.26 | 0.20 ± 0.11 |
| AHPR (mV s−1) | 59 ± 57 * | 123 ± 42 # | 23 ± 32 # | 31 ± 31 # | 22 ± 50 * | 122 ± 80 # | 3 ± 9 # | 11 ± 20 # |
| dAHP (V s−1) | 0.46 ± 1.01 | 0.00 ± 0.00 # | 1.40 ± 1.39 #† | 0.00 ± 0.00 † | 0.40 ± 0.80 | 0.00 ± 0.00 # | 0.73 ± 0.97 #† | 0.00 ± 0.00 † |
| Spike width (ms) | 1.57 ± 0.58 * | 1.48 ± 0.53 § | 1.23 ± 0.36 § † | 2.01 ± 0.61 † | 2.23 ± 0.75 * | 2.42 ± 0.44 § # | 1.76 ± 0.49 § # † | 2.98 ± 0.59 † |
| Spike height (mV) | 71.2 ± 11.4 * | 75.0 ± 11.8 | 70.2 ± 13.3 | 68.3 ± 10.3 | 60.3 ± 16.0 * | 54.6 ± 18.7 | 64.7 ± 11.9 | 55.2 ± 21.0 |
| AHP (mV) | 22.4 ± 5.2 * | 25.1 ± 5.8 # | 17.9 ± 1.2 # | 24.1 ± 4.6 § | 18.1 ± 5.4 * | 19.1 ± 3.0 | 19.5 ± 6.0 | 15.2 ± 4.1 § |
| Concavity (mV) | −0.93 ± 1.14 | −2.07 ± 1.23 # | −0.41 ± 0.61 # | −0.31 ± 0.43 # | −0.28 ± 0.55 | −1.11 ± 0.60 # | −0.09 ± 0.28 # | −0.26 ± 0.62 # |
| Convexity (mV) | 0.89 ± 0.49 | 0.64 ± 0.30 | 0.93 ± 0.56 | 1.11 ± 0.53 | 0.97 ± 0.64 | 0.48 ± 0.17 | 1.22 ± 0.73 | 0.75 ± 0.40 |