Article: Synaptic ionotropic glutamate receptors and plasticity are developmentally altered in the CA1 field of Fmr1 knockout mice.

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Pilpel Y; Kolleker A; Berberich S; Ginger M; Frick A; Mientjes E; Oostra BA; Seeburg PH
J. Physiol. (Lond.), 2009

Table 1. Intrinsic excitability of hippocampal CA1 pyramidal cells at P14

Measurement	WT	Fmr1 KO2	P value^c
Measurements were made by whole-cell recordings in WT (n = 12) and Fmr1 KO cells (n = 18).^a Injected current required to evoke one spike (600 ms);^b 600 ms current injection;^c Student's unpaired t test; *mAHP, membrane afterhyperpolarization.
Resting membrane potential (mV)	−65.6 ± 3.2	65.8 ± 2.9	0.82
Input resistance (MΩ)	151 ± 63	155 ± 32	0.84
mAHP* amplitude (mV)	6.3 ± 3.5	6.1 ± 3.2	0.93
Spike threshold (mV)	−49.0 ± 3.2	−50.8 ± 3.1	0.13
Rheobase (Rh; pA)^a	70 ± 28	52 ± 28	0.1
Number of spikes at (Rh + 20 mV)^b	7.5 ± 4.5	7.5 ± 3.1	1

Inferred neuron-electrophysiology data values

Neuron Type	Ephys Prop	Extracted Value	Standardized Value	Content Source
Hippocampus CA1 pyramidal cell	AHP amplitude (mV)	6.3 ± 3.5 (12)	6.3 (mV)	Data Table
Hippocampus CA1 pyramidal cell	spike threshold (mV)	-49.0 ± 3.2 (12)	-49.0 (mV)	Data Table
Hippocampus CA1 pyramidal cell	rheobase	70.0 ± 28.0 (12)	70.0 (pA)	Data Table
Hippocampus CA1 pyramidal cell	resting membrane potential (mV)	-65.6 ± 3.2 (12)	-65.6 (mV)	Data Table
Hippocampus CA1 pyramidal cell	input resistance (MΩ)	151.0 ± 63.0 (12)	151.0 (MΩ)	Data Table