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Article: Anatomy, physiology, and synaptic responses of rat layer V auditory cortical cells and effects of intracellular GABA(A) blockade.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Hefti BJ; Smith PH
J. Neurophysiol., 2000


Table 1.

Comparisons of IB and RS cell anatomy, intrinsic physiological properties, and synaptic responses

RS IB
V rest, mV −66.2 ± 4.0 −66.4 ± 4.0
R in, MΩ 49.2 ± 14.7 30.7 ± 8.6*
First spike half-width, ms 0.93 ± 0.25 0.72 ± 0.14*
Fifth spike half-width, ms 1.23 ± 0.46† 0.76 ± 0.15*
EPSP latency, ms 2.8 ± 1.6 2.5 ± 1.6
GABAApresent 50 of 56 16 of 36‡
GABABpresent 50 of 56 1 of 36‡
IPSP latency, ms 4.4 ± 1.7§ 3.5 ± 1.1* §
Fast IPSP (GABAA) reversal, mV −60.7 ± 3.6 −62.1 ± 5.0
Suprathreshold at rest 16 of 56 27 of 36‡
Soma size, μm2 145 ± 21 212 ± 22*
Apical dendrite diameter
 50 μm 2.2 ± 0.4 3.8 ± 0.7*
 200 μm 2.0 ± 1.3 3.3 ± 0.6*
 400 μm 0.8 ± 0.4 2.7 ± 0.4*
Branches from apical dendrite
 Layer V 4.8 ± 2.6 7.9 ± 4.8
 Layer IV 3.4 ± 1.8 10.0 ± 3.3*
 Layer III 0.8 ± 0.8 5.7 ± 1.9*
 Layer II 0.1 ± 0.3 0.8 ± 0.9*
Total branches in layer I 0.6 ± 1.3 13.1 ± 3.4*

  • Values are means ± SD. Number of RS neurons is 67 and IB neurons is 39. RS, regular spiking; IB, intrinsic bursting; EPSP, excitatory postsynaptic potential; IPSP, inhibitory postsynaptic potential. * Statistically significant difference of at leastP < 0.05 using a 2 sample t-test when comparing the RS cell value to the IB cell value. † Statistically significant (P < 0.05) for the comparison of RS cell 1st and 5th spikes. ‡ Statistical significance of at leastP < 0.05 using a χ2 test when comparing the RS to the IB cell numbers. § EPSP latencies were significantly shorter (P < 0.01) than IPSP latencies in both IB and RS cells.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 primary auditory cortex layer 5 regular spiking slender tufted neurons resting membrane potential (mV) -66.2 ± 4.0 (67) -66.2 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary auditory cortex layer 5 intrinsically bursting thick tufted neurons resting membrane potential (mV) -66.4 ± 4.0 (39) -66.4 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary auditory cortex layer 5 regular spiking slender tufted neurons input resistance (MΩ) 49.2 ± 14.7 (67) 49.2 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 primary auditory cortex layer 5 intrinsically bursting thick tufted neurons input resistance (MΩ) 30.7 ± 8.6 (39) 30.7 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 primary auditory cortex layer 5 regular spiking slender tufted neurons spike half-width (ms) 0.93 ± 0.25 (67) 0.93 (ms) Data Table
Neocortex pyramidal cell layer 5-6 primary auditory cortex layer 5 intrinsically bursting thick tufted neurons spike half-width (ms) 0.72 ± 0.14 (39) 0.72 (ms) Data Table