Table 1Comparison of the intrinsic properties of layer V pyramidal neurons from wild-type (+/+) and Kcna1-null (−/−) mice*
+/+ (n=5)
−/− (n=6)
RMP, mV
−69.8±3.48
−70.7±4.14
RN, MΩ
116.6±18.7
81.7±10.1
AP Amplitude, mV
95.6±1.86
90.3±6.58
AP Threshold, mV
−38.2±2.60
−44.7±2.86
AP Width at base, ms
1.14±0.11
1.17±0.21
AP Half-width, ms
0.70±0.04
0.72±0.11
*Values are reported as mean±S.E.M. Number of neurons is indicated in parentheses; RN, input resistance calculated from peak voltage responses to small (5–10mV) hyperpolarizing current pulses; RMP, resting membrane potential; AP, action potential; AP Amplitude, peak AP amplitude measured from RMP; AP Threshold, AP threshold relative to RMP measured from the inflection point just prior to the AP upstroke; AP Width at base, width of the AP measured at threshold; AP Half-width, width of the AP measured at a point halfway between threshold and peak.
