Table 1Overview of intrinsic cellular properties of CA1 pyramidal neurones
Saline
Toxin
P
n=25
n=22
Passive properties
Resting membrane potential
(mV)
−62.3±0.9
−61.6±1.2
n.s.
Input resistance
(MΩ)
33.3±1.6
32.3±2.4
n.s.
Membrane capacitance
(pF)
43.4±3.2
39.1±3.7
n.s.
First action potential evoked by a 0.1-s current injection
Depolarising pre-potential
(mV)
3.9±0.5
2.8±0.7
n.s.
Action potential threshold
(mV)
−52.2±0.9
−50.2±0.6
n.s.
Action potential amplitude
(mV)
78.6±2.0
71.6±1.8
<0.01
Maximum rate of rise
(V s−1)
330±28
223±8
<0.001
Maximum repolarisation rate
(V s−1)
108±4
98±4
<0.05
Fast AHP amplitude
(mV)
10.8±0.4
7.3±0.5
<0.01
Late AHP induced by a 0.1-s 1.4-nA current injection
Number of action potentials
7.0±0.3
7.8±0.3
n.s.
Medium AHP amplitude
(mV)
5.2±0.7
3.7±0.4
n.s.
Slow AHP amplitude
(mV)
3.7±0.5
1.7±0.4
<0.01
For methods of quantification, see text and Fig. 1. Data are given as mean±S.E.M. P values for effect of experimental group (toxin and control) obtained from GLM analysis with rats ‘nested’ within the experimental groups.
