Article: Developmental sensitivity of hippocampal interneurons to ethanol: involvement of the hyperpolarization-activated current, Ih.

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Yan H; Li Q; Fleming R; Madison RD; Wilson WA; Swartzwelder HS
J. Neurophysiol., 2009

TABLE 1.

Membrane properties of CA1 interneurons and pyramidal neurons from adolescent and adult rats

Parameters	Adolescent	n	Adult	n
Interneurons with sAP
Resting membrane potential, mV	−67.4 ± 0.5	23	−67.7 ± 0.6	20
Input resistance, MΩ	169.5 ± 8.7**	23	179.1 ± 13.9**	20
sAP frequency, Hz	4.7 ± 1.3	23	4.6 ± 0.9	20
sAP amplitude, mV	74.9 ± 2.4	23	79.3 ± 2.9	20
Capacitance, pF	23.9 ± 1.1	23	22.1 ± 1.0	20
Interneurons without sAP
Resting membrane potential, mV	−68.3 ± 0.5	61	−68.6 ± 0.5	55
Input resistance, MΩ	173.9 ± 11.5**	61	171.5 ± 15.0*	55
Capacitance, pF	23.6 ± 0.8	61	22.7 ± 0.9	55
Pyramidal neurons
Resting membrane potential, mV	−67.8 ± 1.0	11	−67.2 ± 0.5	11
Input resistance, MΩ	105.8 ± 16.3	11	104.4 ± 15.7	11
Capacitance, pF	25.5 ± 1.5	11	25.0 ± 1.5	11

Values are mean ± SE. sAP amplitudes were measured from the action potential threshold. sAP, spontaneous action potential.
↵* P < 0.05,
↵** P < 0.01 (Compared with pyramidal neurons in each age group).

Inferred neuron-electrophysiology data values

Neuron Type	Ephys Prop	Extracted Value	Standardized Value	Content Source
Hippocampus CA1 pyramidal cell	resting membrane potential (mV)	-67.8 ± 1.0 (11)	-67.8 (mV)	Data Table
Hippocampus CA1 pyramidal cell	resting membrane potential (mV)	-67.2 ± 0.5 (20)	-67.2 (mV)	Data Table
Hippocampus CA1 pyramidal cell	input resistance (MΩ)	105.8 ± 16.3 (11)	105.8 (MΩ)	Data Table
Hippocampus CA1 pyramidal cell	input resistance (MΩ)	104.4 ± 15.7 (20)	104.4 (MΩ)	Data Table
Hippocampus CA1 pyramidal cell	cell capacitance (pF)	25.5 ± 1.5 (11)	25.5 (pF)	Data Table
Hippocampus CA1 pyramidal cell	cell capacitance (pF)	25.0 ± 1.5 (20)	25.0 (pF)	Data Table