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Article: Neurophysiological modification of CA1 pyramidal neurons in a transgenic mouse expressing a truncated form of disrupted-in-schizophrenia 1.

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Booth CA; Brown JT; Randall AD
Eur. J. Neurosci., 2014


Table 1. Passive membrane properties (mean ± SEM) of CA1-PNs from 3- to 4-month-old DISC1tr and WT littermates
WT (n = 19)DISC1tr (n = 23) P
RMP (mV)-80.0 ± 1.0-80.5 ± 0.80.7
Ri (MΩ)127 ± 9126 ± 100.6
τM (ms)20.2 ± 1.220.2 ± 1.31
Sag (%)26.7 ± 1.226.6 ± 1.21
Max -ve deflection (mV)11.8 ± 0.811.7 ± 0.90.5
Rebound on repol (mV)2.3 ± 0.22.3 ± 0.11

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell membrane time constant (ms) 20.2 ± 1.2 (19) 20.2 (ms) Data Table
Hippocampus CA1 pyramidal cell sag ratio 26.7 ± 1.2 (19) 0.267 (ratio) Data Table
Hippocampus CA1 pyramidal cell AHP amplitude (mV) 11.8 ± 0.8 (19) 11.8 (mV) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -80.0 ± 1.0 (19) -80.0 (mV) Data Table
Hippocampus CA1 pyramidal cell ADP amplitude (mV) 2.3 ± 0.2 (19) 2.3 (mV) Data Table
Hippocampus CA1 pyramidal cell input resistance (MΩ) 127.0 ± 9.0 (19) 127.0 (MΩ) Data Table