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Article: Early postnatal plasticity in neocortex of Fmr1 knockout mice.

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Desai NS; Casimiro TM; Gruber SM; Vanderklish PW
J. Neurophysiol., 2006



TABLE 1.Intrinsic properties of pyramidal neurons
Wild-type Knockout
Vm, mV –66.3 ± 0.8 –65.6 ± 0.9
Rin, MΩ 286 ± 23 293 ± 22
τ, ms 30 ± 2 33 ± 2
Ith, pA 61 ± 6 57 ± 6
Vth, mV –40.8 ± 0.7 –41.3 ± 0.7
Sag, mV 2.5 ± 0.3 2.7 ± 0.3
A summary of the basic intrinsic properties of layer V pyramidal neurons in somatosensory cortex of wild-type (n = 24) and Fmr1 knockout (KO) (n = 31) mice. These include resting potential (Vm), resting input resistance (Rin), time constant (τ), threshold or rheobase current (Ith), threshold potential (Vth), and sag potential (mV, measured from the response to a –100-pA step). Mean values are shown ± SE. No differences are significant.

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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 pyramidal neurons input resistance (MΩ) 286.0 ± 23.0 286.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 pyramidal neurons membrane time constant (ms) 30.0 ± 2.0 30.0 (ms) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 pyramidal neurons rheobase (pA) 61.0 ± 6.0 61.0 (pA) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 pyramidal neurons spike threshold (mV) -40.8 ± 0.7 -40.8 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 pyramidal neurons sag amplitude (mV) 2.5 ± 0.3 2.5 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 pyramidal neurons resting membrane potential (mV) -66.3 ± 0.8 -66.3 (mV) Data Table