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Article: Transgenic mouse lines subdivide external segment of the globus pallidus (GPe) neurons and reveal distinct GPe output pathways.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Mastro KJ; Bouchard RS; Holt HA; Gittis AH
J. Neurosci., 2014


Table 1.

Intrinsic properties of GPe neurons

Lhx6 PV
n 40 30
Input resistance (MΩ) 301 ± 168 170 ± 16**
Capacitance (pF) 164 ± 65 241 ± 113**
Vm rest (mV) -71.7 ± 7.2 -68.9 ± 5.5
AP threshold (mV) -55.4 ± 14.1 -55.7 ± 4.4
AP half-width (ms) 0.37 ± 0.11 0.28 ± 0.09**
Afterhyperpolarization (mV) 19.3 ± 4.0 21.9 ± 4.7*
Maximum firing rate (Hz) 249 ± 80 347 ± 80**
Adaptation ratio (Hz) 0.80 ± 0.11 0.81 ± 0.03
Linear slope (Hz/nA) 491 ± 164 494 ± 287
Cell-attached firing rate (Hz) 34 ± 33 62 ± 34**
Cell-attached CV 0.31 ± 0.39 0.22 ± 0.25
Whole-cell firing rate (Hz) 7.8 ± 14.2 28 ± 25**
Sag (mV) 16.1 ± 7.0 13.8 ± 5.5

  • Summary of intrinsic parameters recorded in Lhx6-GPe and PV-GPe neurons.

  • ↵**p < 0.01;

  • ↵*p < 0.05. Values for AP threshold and Vm rest were corrected for liquid junction potential (12 mV). Values are mean ± SD.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Globus pallidus intrinsic cell Medial Globus pallidus Lhx6- expressing neurons resting membrane potential (mV) -71.7 ± 7.2 (40) -71.7 (mV) Data Table
Globus pallidus intrinsic cell Lateral globus pallidus parvalbumin-expressing neurons resting membrane potential (mV) -68.9 ± 5.5 (30) -68.9 (mV) Data Table
Globus pallidus intrinsic cell Medial Globus pallidus Lhx6- expressing neurons spike threshold (mV) -55.4 ± 14.1 (40) -55.4 (mV) Data Table
Globus pallidus intrinsic cell Lateral globus pallidus parvalbumin-expressing neurons spike threshold (mV) -55.7 ± 4.4 (30) -55.7 (mV) Data Table
Globus pallidus intrinsic cell Medial Globus pallidus Lhx6- expressing neurons spike half-width (ms) 0.37 ± 0.11 (40) 0.37 (ms) Data Table
Globus pallidus intrinsic cell Lateral globus pallidus parvalbumin-expressing neurons spike half-width (ms) 0.28 ± 0.09 (30) 0.28 (ms) Data Table
Globus pallidus intrinsic cell Medial Globus pallidus Lhx6- expressing neurons AHP amplitude (mV) 19.3 ± 4.0 (40) 19.3 (mV) Data Table
Globus pallidus intrinsic cell Lateral globus pallidus parvalbumin-expressing neurons AHP amplitude (mV) 21.9 ± 4.7 (30) 21.9 (mV) Data Table
Globus pallidus intrinsic cell Medial Globus pallidus Lhx6- expressing neurons maximum firing rate (Hz) 249.0 ± 80.0 (40) 249.0 (Hz) Data Table
Globus pallidus intrinsic cell Lateral globus pallidus parvalbumin-expressing neurons maximum firing rate (Hz) 347.0 ± 80.0 (30) 347.0 (Hz) Data Table
Globus pallidus intrinsic cell Medial Globus pallidus Lhx6- expressing neurons adaptation ratio (Hz) 0.8 ± 0.11 (40) 0.8 (ratio) Data Table
Globus pallidus intrinsic cell Lateral globus pallidus parvalbumin-expressing neurons adaptation ratio (Hz) 0.81 ± 0.03 (30) 0.81 (ratio) Data Table
Globus pallidus intrinsic cell Medial Globus pallidus Lhx6- expressing neurons FI slope (Hz/nA) 491.0 ± 164.0 (40) 491.0 (Hz/nA) Data Table
Globus pallidus intrinsic cell Lateral globus pallidus parvalbumin-expressing neurons FI slope (Hz/nA) 494.0 ± 287.0 (30) 494.0 (Hz/nA) Data Table
Globus pallidus intrinsic cell Medial Globus pallidus Lhx6- expressing neurons firing frequency (Hz) 7.8 ± 14.2 (40) 7.8 (Hz) Data Table
Globus pallidus intrinsic cell Lateral globus pallidus parvalbumin-expressing neurons firing frequency (Hz) 28.0 ± 25.0 (30) 28.0 (Hz) Data Table
Globus pallidus intrinsic cell Medial Globus pallidus Lhx6- expressing neurons sag amplitude (mV) 16.1 ± 7.0 (40) 16.1 (mV) Data Table
Globus pallidus intrinsic cell Lateral globus pallidus parvalbumin-expressing neurons sag amplitude (mV) 13.8 ± 5.5 (30) 13.8 (mV) Data Table
Globus pallidus intrinsic cell Medial Globus pallidus Lhx6- expressing neurons input resistance (MΩ) 301.0 ± 168.0 (40) 301.0 (MΩ) Data Table
Globus pallidus intrinsic cell Lateral globus pallidus parvalbumin-expressing neurons input resistance (MΩ) 170.0 ± 16.0 (30) 170.0 (MΩ) Data Table
Globus pallidus intrinsic cell Medial Globus pallidus Lhx6- expressing neurons cell capacitance (pF) 164.0 ± 65.0 (40) 164.0 (pF) Data Table
Globus pallidus intrinsic cell Lateral globus pallidus parvalbumin-expressing neurons cell capacitance (pF) 241.0 ± 113.0 (30) 241.0 (pF) Data Table