Article: Aging-Related Hyperexcitability in CA3 Pyramidal Neurons Is Mediated by Enhanced A-Type K+ Channel Function and Expression.

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Simkin D; Hattori S; Ybarra N; Musial TF; Buss EW; Richter H; Oh MM; Nicholson DA; Disterhoft JF
J. Neurosci., 2015

Table 3.

fAHP and AP half-width evoked synaptically or by direct somatic current injection with control (KMeth) or phrixotoxin in the internal pipette solution

Group	1 orthodromic APs		Somatic current injection ramp
Group	fAHP (mV)	AP half-width_Vh (ms)	fAHP I_RAMP (mV)	AP half-width_thresh (ms)
Young-control (n = 43)	-57.88 ± 0.32	1.15 ± 0.02	-50.94 ± 0.63 (42)	1.16 ± 0.02
Young-PaTx (n = 7)	-56.79 ± 0.53	1.18 ± 0.03
Aged-control (n = 28)	-61.68 ± 0.61^***	0.98 ± 0.02^**	-53.76 ± 0.74 (28)^**	1.09 ± 0.02^*
Aged-PaTx (n = 8)	-56.25 ± 0.61	1.13 ± 0.02

↵*p < 0.05;
↵**p < 0.005;
↵***p < 0.0005.

Report miscurated data

Inferred neuron-electrophysiology data values

Neuron Type	Ephys Prop	Extracted Value	Standardized Value	Content Source
Hippocampus CA3 pyramidal cell	fast AHP amplitude (mV)	-50.94 ± 0.63 (42)	--	Data Table
Hippocampus CA3 pyramidal cell	spike half-width (ms)	1.16 ± 0.02 (43)	1.16 (ms)	Data Table
Hippocampus CA3 pyramidal cell	fast AHP amplitude (mV)	-53.76 ± 0.74 (28)	--	Data Table
Hippocampus CA3 pyramidal cell	spike half-width (ms)	1.09 ± 0.02 (28)	1.09 (ms)	Data Table