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Article: Impaired firing properties of dentate granule neurons in an Alzheimer's disease animal model are rescued by PPARγ agonism.

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Nenov MN; Tempia F; Denner L; Dineley KT; Laezza F
J. Neurophysiol., 2015


Table 6.

Comparison of firing, active, and passive properties of type II DG granule cells between wild-type and RSG-treated wild-type

DG GC Type IIWild-type, n = 8Wild-type + RSG, n = 8P
MRP, mV-69.2 ± 0.9-72.6 ± 2.50.25
Vtrh, mV-45.2 ± 2.7-43 ± 2.50.56
Itrh, mV41.3 ± 5.542.5 ± 6.50.88
Cm, pF108.7 ± 9112 ± 15.10.86
Rin, MΩ297.2 ± 13.6377.3 ± 12.90.001*
τ, ms31.9 ± 1.842.78 ± 6.40.14
fAHP, mV-12.1 ± 1.2-15.3 ± 2.10.21
ADP, mV3.1 ± 0.63.3 ± 0.80.77
sAHP, mV-10.7 ± 0.9-14.4 ± 1.90.1
Number of APs at Current Step of
140, pA11.9 ± 1.411.8 ± 1.20.95
150, pA12.8 ± 1.412.6 ± 1.20.95
160, pA13.4 ± 1.412.5 ± 1.20.64
170, pA14 ± 1.413.5 ± 1.30.8
180, pA14.9 ± 1.413.8 ± 1.20.56
190, pA15.1 ± 1.514.6 ± 1.30.81
200, pA15.6 ± 1.615.5 ± 1.20.95
210, pA16.4 ± 1.515.9 ± 1.30.8
220, pA17.3 ± 1.516.5 ± 1.20.7
Instantaneous Firing Frequency (Hz) at Current Step of
180, pA35.4 ± 2.130.4 ± 2.40.13
190, pA36.5 ± 2.231.7 ± 2.40.16

  • Data are mean ± SE.

  • ↵* P values obtained with Student's t-test.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dentate gyrus granule cell Type II dentate gyrus granule cell resting membrane potential (mV) -69.2 ± 0.9 (8) -69.2 (mV) Data Table
Dentate gyrus granule cell Type II dentate gyrus granule cell spike threshold (mV) -45.2 ± 2.7 (8) -45.2 (mV) Data Table
Dentate gyrus granule cell Type II dentate gyrus granule cell cell capacitance (pF) 108.7 ± 9.0 (8) 108.7 (pF) Data Table
Dentate gyrus granule cell Type II dentate gyrus granule cell input resistance (MΩ) 297.2 ± 13.6 (8) 297.2 (MΩ) Data Table
Dentate gyrus granule cell Type II dentate gyrus granule cell membrane time constant (ms) 31.9 ± 1.8 (8) 31.9 (ms) Data Table
Dentate gyrus granule cell Type II dentate gyrus granule cell fast AHP amplitude (mV) -12.1 ± 1.2 (8) 12.1 (mV) Data Table
Dentate gyrus granule cell Type II dentate gyrus granule cell ADP amplitude (mV) 3.1 ± 0.6 (8) 3.1 (mV) Data Table
Dentate gyrus granule cell Type II dentate gyrus granule cell slow AHP amplitude (mV) -10.7 ± 0.9 (8) 10.7 (mV) Data Table
Dentate gyrus granule cell Type II dentate gyrus granule cell firing frequency (pA) 35.4 ± 2.1 (8) -- Data Table