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Article: Antiepileptic efficacy of topiramate: assessment in two in vitro seizure models.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Jahromi SS; Pelletier MR; McDonald PJ; Khosravani H; Carlen PL
Brain Res., 2000

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell Hippocampus CA1 pyramidal neuron ADP amplitude (mV) 11.8 ± 0.8 (10) 11.8 (mV) Data Table
Hippocampus CA1 pyramidal cell Hippocampus CA1 pyramidal neuron fast AHP amplitude (mV) -13.9 ± 0.9 (10) 13.9 (mV) Data Table
Hippocampus CA1 pyramidal cell Hippocampus CA1 pyramidal neuron input resistance (MΩ) 47.8 ± 12.7 (10) 47.8 (MΩ) Data Table
Hippocampus CA1 pyramidal cell Hippocampus CA1 pyramidal neuron resting membrane potential (mV) -62.3 ± 1.8 (10) -62.3 (mV) Data Table
Hippocampus CA1 pyramidal cell Hippocampus CA1 pyramidal neuron slow AHP amplitude (mV) -11.3 ± 0.8 (10) 11.3 (mV) Data Table
Hippocampus CA1 pyramidal cell Hippocampus CA1 pyramidal neuron spike amplitude (mV) 106.3 ± 2.8 (10) 106.3 (mV) Data Table
Hippocampus CA1 pyramidal cell Hippocampus CA1 pyramidal neuron spike threshold (mV) 40.6 ± 1.6 (10) -40.6 (mV) Data Table

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Metadata values

Experimental condition Value
Species Rats
ElectrodeType Patch-clamp
PrepType in vitro
Strain Wistar
RecTemp 34.0
ExternalSolution 5.0
InternalSolution 5.0
AnimalAge 22.0 - 40.0
JxnPotential Unreported
internal_0_pH 7.2
internal_0_Mg 2.0
internal_0_K 140.0
internal_0_ATP 275.0
internal_0_HEPES 10.0
external_0_Mg 2.0
external_0_Na 152.25
external_0_K 2.5
external_0_Cl 135.5
external_0_Ca 2.0
external_0_glucose 10.0

Data table listing

Data Table Article Title Authors Journal Year Table needs expert? Ephys table mentions Curated by Times validated
26840 Antiepileptic efficacy of topiramate: assessment in two in vitro seizure models. Jahromi SS; Pelletier MR; McDonald PJ; Khosravani H; Carlen PL Brain Res. 2000 True 7 Shreejoy Tripathy, Dmitry Tebaykin, Athanasios Kritharis, Hannah Sangra, Patrick Savage, 2