AboutNeuron TypesElectrophysiology PropertiesArticlesFAQsData/APIGet Involved

Article: The FGF14(F145S) mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Laezza F; Gerber BR; Lou JY; Kozel MA; Hartman H; Craig AM; Ornitz DM; Nerbonne JM
J. Neurosci., 2007

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other cultured hippocampus neurons cell capacitance (pF) 44.0 ± 3.0 (30) 44.0 (pF) Data Table
Other cultured hippocampus neurons input resistance (GΩ) 0.7 ± 0.1 (30) 700.0 (MΩ) Data Table
Other cultured hippocampus neurons resting membrane potential (mV) -56.0 ± 1.0 (30) -56.0 (mV) Data Table
Other cultured hippocampus neurons rheobase (pA) 38.0 ± 6.0 (30) 38.0 (pA) Data Table
Other cultured hippocampus neurons spike amplitude (mV) 81.0 ± 2.0 (30) 81.0 (mV) Data Table
Other cultured hippocampus neurons spike half-width (ms) 3.7 ± 0.3 (30) 3.7 (ms) Data Table
Other cultured hippocampus neurons spike threshold (mV) -28.0 ± 0.9 (30) -28.0 (mV) Data Table

Report miscurated data

Metadata values

Experimental condition Value
Species Rats
ElectrodeType Patch-clamp
PrepType in vitro
PrepType cell culture
RecTemp 20.0 - 22.0
ExternalSolution 5.0
InternalSolution 5.0
JxnPotential Unreported
AnimalAge 18.0
internal_0_pH 7.3
internal_0_Na 10.0
internal_0_EGTA 1.0
internal_0_HEPES 10.0
internal_0_Cl 10.0
internal_0_Cs 140.0
external_0_pH 7.3
external_0_Mg 1.0
external_0_Na 140.0
external_0_K 3.0
external_0_HEPES 20.0
external_0_Cl 147.0
external_0_Ca 1.0
external_0_CNQX 6.0
external_0_BIC 10.0
external_0_DAPV 100.0

Data table listing

Data Table Article Title Authors Journal Year Table needs expert? Ephys table mentions Curated by Times validated
2134 The FGF14(F145S) mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability. Laezza F; Gerber BR; Lou JY; Kozel MA; Hartman H; Craig AM; Ornitz DM; Nerbonne JM J. Neurosci. 2007 False 7 Shreejoy Tripathy, Ryan Sefidpour, 3
2133 The FGF14(F145S) mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability. Laezza F; Gerber BR; Lou JY; Kozel MA; Hartman H; Craig AM; Ornitz DM; Nerbonne JM J. Neurosci. 2007 False 0 None