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Article: The FGF14(F145S) mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Laezza F; Gerber BR; Lou JY; Kozel MA; Hartman H; Craig AM; Ornitz DM; Nerbonne JM J. Neurosci., 2007
Metadata values
| Experimental condition | Value |
|---|---|
| Species | Rats |
| ElectrodeType | Patch-clamp |
| PrepType | in vitro |
| PrepType | cell culture |
| RecTemp | 20.0 - 22.0 |
| ExternalSolution | 5.0 |
| InternalSolution | 5.0 |
| JxnPotential | Unreported |
| AnimalAge | 18.0 |
| internal_0_pH | 7.3 |
| internal_0_Na | 10.0 |
| internal_0_EGTA | 1.0 |
| internal_0_HEPES | 10.0 |
| internal_0_Cl | 10.0 |
| internal_0_Cs | 140.0 |
| external_0_pH | 7.3 |
| external_0_Mg | 1.0 |
| external_0_Na | 140.0 |
| external_0_K | 3.0 |
| external_0_HEPES | 20.0 |
| external_0_Cl | 147.0 |
| external_0_Ca | 1.0 |
| external_0_CNQX | 6.0 |
| external_0_BIC | 10.0 |
| external_0_DAPV | 100.0 |