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Article: Intrinsic membrane properties of locus coeruleus neurons in Mecp2-null mice.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Zhang X; Cui N; Wu Z; Su J; Tadepalli JS; Sekizar S; Jiang C
Am. J. Physiol., Cell Physiol., 2010

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Locus coeruleus noradrenergic neuron Locus coeruleus GFP-expressing TH-expressing noradrenergic neuron adaptation ratio (last/first ISI) 1.47 ± 0.07 1.47 (ratio) Data Table
Locus coeruleus noradrenergic neuron Locus coeruleus GFP-expressing TH-expressing noradrenergic neuron input resistance (MΩ) 492.0 ± 26.0 492.0 (MΩ) Data Table
Locus coeruleus noradrenergic neuron Locus coeruleus GFP-expressing TH-expressing noradrenergic neuron medium AHP amplitude (mV) 27.02 ± 0.66 27.02 (mV) Data Table
Locus coeruleus noradrenergic neuron Locus coeruleus GFP-expressing TH-expressing noradrenergic neuron membrane time constant (ms) 33.3 ± 1.6 33.3 (ms) Data Table
Locus coeruleus noradrenergic neuron Locus coeruleus GFP-expressing TH-expressing noradrenergic neuron resting membrane potential (mV) -53.8 ± 0.7 -53.8 (mV) Data Table
Locus coeruleus noradrenergic neuron Locus coeruleus GFP-expressing TH-expressing noradrenergic neuron spike amplitude (mV) 89.2 ± 1.17 89.2 (mV) Data Table
Locus coeruleus noradrenergic neuron Locus coeruleus GFP-expressing TH-expressing noradrenergic neuron spike decay time (ms) 0.79 ± 0.03 0.79 (ms) Data Table
Locus coeruleus noradrenergic neuron Locus coeruleus GFP-expressing TH-expressing noradrenergic neuron spike half-width (ms) 1.05 ± 0.02 1.05 (ms) Data Table
Locus coeruleus noradrenergic neuron Locus coeruleus GFP-expressing TH-expressing noradrenergic neuron spike rise time (ms) 0.63 ± 0.01 0.63 (ms) Data Table
Locus coeruleus noradrenergic neuron Locus coeruleus GFP-expressing TH-expressing noradrenergic neuron spike threshold (mV) -40.29 ± 0.46 -40.29 (mV) Data Table
Locus coeruleus noradrenergic neuron Locus coeruleus GFP-expressing TH-expressing noradrenergic neuron spontaneous firing rate (Hz) 4.0 ± 0.4 4.0 (Hz) Data Table

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Metadata values

Experimental condition Value
Species Mice
ElectrodeType Patch-clamp
PrepType in vitro
JxnPotential Unreported
AnimalAge 21.0 - 28.0
RecTemp 31.0 - 35.0
InternalSolution 5.0
ExternalSolution 5.0
Strain C57BL
Strain Other
internal_0_pH 7.3
internal_0_Mg 2.0
internal_0_Na 0.3
internal_0_K 140.0
internal_0_GTP 0.3
internal_0_ATP 2.0
internal_0_EGTA 0.4
internal_0_HEPES 10.0
internal_0_Cl 10.0
external_0_Mg 2.0
external_0_Na 151.25
external_0_K 3.0
external_0_Cl 135.0
external_0_Ca 2.0
external_0_glucose 10.0

Data table listing

Data Table Article Title Authors Journal Year Table needs expert? Ephys table mentions Curated by Times validated
49872 Intrinsic membrane properties of locus coeruleus neurons in Mecp2-null mice. Zhang X; Cui N; Wu Z; Su J; Tadepalli JS; Sekizar S; Jiang C Am. J. Physiol., Cell Physiol. 2010 False 11 Shreejoy Tripathy, Kerrie Tsigounis, Ryan Sefidpour, 2
49870 Intrinsic membrane properties of locus coeruleus neurons in Mecp2-null mice. Zhang X; Cui N; Wu Z; Su J; Tadepalli JS; Sekizar S; Jiang C Am. J. Physiol., Cell Physiol. 2010 False 0 None
49871 Intrinsic membrane properties of locus coeruleus neurons in Mecp2-null mice. Zhang X; Cui N; Wu Z; Su J; Tadepalli JS; Sekizar S; Jiang C Am. J. Physiol., Cell Physiol. 2010 False 0 None