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Article: A seizure-induced gain-of-function in BK channels is associated with elevated firing activity in neocortical pyramidal neurons.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Shruti S; Clem RL; Barth AL
Neurobiol. Dis., 2008

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex pyramidal cell layer 2-3 Primary Somatosensory Barrel Cortex Layer 2/3 Pyramidal Neuron input resistance (MΩ) 378.84 ± 79.87 378.84 (MΩ) Data Table
Neocortex pyramidal cell layer 2-3 Primary Somatosensory Barrel Cortex Layer 2/3 Pyramidal Neuron resting membrane potential (mV) -71.18 ± 3.51 -71.18 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Primary Somatosensory Barrel Cortex Layer 2/3 Pyramidal Neuron rheobase (pA) 117.1 ± 41.28 117.1 (pA) Data Table
Neocortex pyramidal cell layer 2-3 Primary Somatosensory Barrel Cortex Layer 2/3 Pyramidal Neuron spike amplitude (mV) 74.71 ± 1.0 74.71 (mV) Data Table
Neocortex pyramidal cell layer 2-3 Primary Somatosensory Barrel Cortex Layer 2/3 Pyramidal Neuron spike decay time (ms) 3.0 ± 0.1 3.0 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Primary Somatosensory Barrel Cortex Layer 2/3 Pyramidal Neuron spike half-width (ms) 2.93 ± 0.07 2.93 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Primary Somatosensory Barrel Cortex Layer 2/3 Pyramidal Neuron spike rise time (ms) 1.52 ± 0.04 1.52 (ms) Data Table
Neocortex pyramidal cell layer 2-3 Primary Somatosensory Barrel Cortex Layer 2/3 Pyramidal Neuron spike threshold (mV) -27.59 ± 0.86 -27.59 (mV) Data Table

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Metadata values

Experimental condition Value
Species Mice
ElectrodeType Patch-clamp
Strain Mice, Inbred C57BL
RecTemp 21.0 - 24.0
InternalSolution 5.0
internal_1_pH 7.275
internal_1_Mg 4.0
internal_1_Na 8.4
internal_1_Cl 8.0
ExternalSolution 5.0
PrepType in vitro
JxnPotential Not corrected
AnimalAge 13.0 - 16.0
internal_0_pH 7.3
internal_0_Mg 4.0
internal_0_Na 8.4
internal_0_K 122.0
internal_0_GTP 0.4
internal_0_ATP 4.0
internal_0_Cl 14.0
external_0_Mg 1.3
external_0_Na 146.2
external_0_K 2.5
external_0_Cl 126.5
external_0_Ca 2.5
external_0_glucose 11.0

Data table listing

Data Table Article Title Authors Journal Year Table needs expert? Ephys table mentions Curated by Times validated
48067 A seizure-induced gain-of-function in BK channels is associated with elevated firing activity in neocortical pyramidal neurons. Shruti S; Clem RL; Barth AL Neurobiol. Dis. 2008 False 8 Patrick Savage, Brenna Li, 1