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Article: Impaired action potential initiation in GABAergic interneurons causes hyperexcitable networks in an epileptic mouse model carrying a human Na(V)1.1 mutation.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Hedrich UB; Liautard C; Kirschenbaum D; Pofahl M; Lavigne J; Liu Y; Theiss S; Slotta J; Escayg A; Dihné M; Beck H; Mantegazza M; Lerche H
J. Neurosci., 2014

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 basket cell Hippocampus CA1 Stratum Oriens fast-spiking inhibitory neuron input resistance (MΩ) 174.9 ± 11.4 (7) 174.9 (MΩ) Data Table
Hippocampus CA1 basket cell Hippocampus CA1 Stratum Oriens fast-spiking inhibitory neuron resting membrane potential (mV) -74.5 ± 5.1 (7) -74.5 (mV) Data Table
Hippocampus CA1 basket cell Hippocampus CA1 Stratum Oriens fast-spiking inhibitory neuron rheobase (pA) 50.0 ± 9.5 (7) 50.0 (pA) Data Table
Hippocampus CA1 basket cell Hippocampus CA1 Stratum Oriens fast-spiking inhibitory neuron spike threshold (mV) -54.4 ± 1.0 (7) -54.4 (mV) Data Table
Hippocampus CA1 basket cell Hippocampus CA1 Stratum Oriens fast-spiking inhibitory neuron spike width (ms) 0.57 ± 0.07 (7) 0.57 (ms) Data Table
Hippocampus CA1 pyramidal cell Hippocampus CA1 stratum pyramidale pyramidal cell input resistance (MΩ) 226.2 ± 14.0 (15) 226.2 (MΩ) Data Table
Hippocampus CA1 pyramidal cell Hippocampus CA1 stratum pyramidale pyramidal cell resting membrane potential (mV) -74.8 ± 1.2 (15) -74.8 (mV) Data Table
Hippocampus CA1 pyramidal cell Hippocampus CA1 stratum pyramidale pyramidal cell rheobase (pA) 50.0 ± 5.9 (15) 50.0 (pA) Data Table
Hippocampus CA1 pyramidal cell Hippocampus CA1 stratum pyramidale pyramidal cell spike threshold (mV) -53.4 ± 1.2 (15) -53.4 (mV) Data Table
Hippocampus CA1 pyramidal cell Hippocampus CA1 stratum pyramidale pyramidal cell spike width (ms) 1.04 ± 0.02 (15) 1.04 (ms) Data Table
Neocortex basket cell Primary somatosensory cortex layer 4 fast-spiking inhibitory neuron input resistance (MΩ) 200.1 ± 16.8 (7) 200.1 (MΩ) Data Table
Neocortex basket cell Primary somatosensory cortex layer 4 fast-spiking inhibitory neuron resting membrane potential (mV) -70.1 ± 1.4 (7) -70.1 (mV) Data Table
Neocortex basket cell Primary somatosensory cortex layer 4 fast-spiking inhibitory neuron rheobase (pA) 92.9 ± 13.0 (7) 92.9 (pA) Data Table
Neocortex basket cell Primary somatosensory cortex layer 4 fast-spiking inhibitory neuron spike threshold (mV) -54.1 ± 1.8 (7) -54.1 (mV) Data Table
Neocortex basket cell Primary somatosensory cortex layer 4 fast-spiking inhibitory neuron spike width (ms) 0.44 ± 0.04 (7) 0.44 (ms) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 pyramidal cell input resistance (MΩ) 140.7 ± 11.2 (17) 140.7 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 pyramidal cell resting membrane potential (mV) -72.9 ± 1.1 (17) -72.9 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 pyramidal cell rheobase (pA) 107.8 ± 9.9 (17) 107.8 (pA) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 pyramidal cell spike threshold (mV) -54.7 ± 1.8 (17) -54.7 (mV) Data Table
Neocortex pyramidal cell layer 5-6 primary somatosensory cortex layer 5 pyramidal cell spike width (ms) 1.02 ± 0.05 (17) 1.02 (ms) Data Table
Thalamic reticular nucleus cell Thalamic reticular nucleus non-bursting GABAergic inhibitory neuron input resistance (MΩ) 303.0 ± 47.9 (7) 303.0 (MΩ) Data Table
Thalamic reticular nucleus cell thalamic reticular nucleus bursting GABAergic inhibitory neuron input resistance (MΩ) 181.4 ± 14.9 (23) 181.4 (MΩ) Data Table
Thalamic reticular nucleus cell Thalamic reticular nucleus non-bursting GABAergic inhibitory neuron resting membrane potential (mV) -72.3 ± 1.7 (7) -72.3 (mV) Data Table
Thalamic reticular nucleus cell thalamic reticular nucleus bursting GABAergic inhibitory neuron resting membrane potential (mV) -68.6 ± 3.5 (23) -68.6 (mV) Data Table
Thalamic reticular nucleus cell Thalamic reticular nucleus non-bursting GABAergic inhibitory neuron rheobase (pA) 59.3 ± 7.4 (7) 59.3 (pA) Data Table
Thalamic reticular nucleus cell thalamic reticular nucleus bursting GABAergic inhibitory neuron rheobase (pA) 47.6 ± 4.5 (23) 47.6 (pA) Data Table
Thalamic reticular nucleus cell Thalamic reticular nucleus non-bursting GABAergic inhibitory neuron spike threshold (mV) -53.1 ± 0.9 (7) -53.1 (mV) Data Table
Thalamic reticular nucleus cell thalamic reticular nucleus bursting GABAergic inhibitory neuron spike threshold (mV) -50.1 ± 4.1 (23) -50.1 (mV) Data Table
Thalamic reticular nucleus cell thalamic reticular nucleus bursting GABAergic inhibitory neuron spike width (ms) 0.65 ± 0.03 (23) 0.65 (ms) Data Table
Thalamic reticular nucleus cell Thalamic reticular nucleus non-bursting GABAergic inhibitory neuron spike width (ms) 1.04 ± 0.07 (7) 1.04 (ms) Data Table
Thalamus relay cell Ventrobasal thalamocortical excitatory relay neuron input resistance (MΩ) 104.5 ± 4.1 (11) 104.5 (MΩ) Data Table
Thalamus relay cell Ventrobasal thalamocortical excitatory relay neuron resting membrane potential (mV) -72.1 ± 1.0 (11) -72.1 (mV) Data Table
Thalamus relay cell Ventrobasal thalamocortical excitatory relay neuron rheobase (pA) 97.7 ± 8.6 (11) 97.7 (pA) Data Table
Thalamus relay cell Ventrobasal thalamocortical excitatory relay neuron spike threshold (mV) -57.3 ± 1.8 (11) -57.3 (mV) Data Table
Thalamus relay cell Ventrobasal thalamocortical excitatory relay neuron spike width (ms) 1.03 ± 0.02 (11) 1.03 (ms) Data Table

Report miscurated data

Metadata values

Experimental condition Value
Species Mice
ElectrodeType Patch-clamp
Strain Mice, Inbred C57BL
PrepType in vitro
ExternalSolution 5.0
InternalSolution 5.0
internal_1_Mg 4.0
internal_1_Na 20.3
internal_1_Cl 105.0
external_1_pH 7.3
external_1_Mg 1.0
external_1_Ca 1.0
external_1_Na 140.0
external_1_Cl 172.2
external_1_K 3.0
external_2_Mg 1.0
external_2_Ca 2.0
external_2_Na 151.25
external_2_Cl 133.5
external_2_K 2.5
internal_2_pH 7.3
internal_2_Mg 2.0
internal_2_Na 2.0
internal_2_Cl 144.0
external_3_Mg 2.0
external_3_Ca 2.0
external_3_Na 50.0
external_3_Cl 154.9
external_3_K 3.5
internal_3_Mg 2.0
internal_3_Na 12.5
internal_3_Cl 4.0
JxnPotential Unreported
AnimalAge 14.0 - 20.0
RecTemp 34.0
internal_0_pH 7.2
internal_0_Mg 6.0
internal_0_Na 20.3
internal_0_K 130.0
internal_0_GTP 0.3
internal_0_ATP 4.0
internal_0_EGTA 10.0
internal_0_HEPES 10.0
internal_0_Cl 9.0
external_0_pH 7.4
external_0_Mg 1.0
external_0_Na 151.25
external_0_K 2.5
external_0_Cl 133.5
external_0_Ca 2.0
external_0_glucose 10.0

Data table listing

Data Table Article Title Authors Journal Year Table needs expert? Ephys table mentions Curated by Times validated
46571 Impaired action potential initiation in GABAergic interneurons causes hyperexcitable networks in an epileptic mouse model carrying a human Na(V)1.1 mutation. Hedrich UB; Liautard C; Kirschenbaum D; Pofahl M; Lavigne J; Liu Y; Theiss S; Slotta J; Escayg A; Dihné M; Beck H; Mantegazza M; Lerche H J. Neurosci. 2014 False 5 Kerrie Tsigounis, Patrick Savage, 1
46573 Impaired action potential initiation in GABAergic interneurons causes hyperexcitable networks in an epileptic mouse model carrying a human Na(V)1.1 mutation. Hedrich UB; Liautard C; Kirschenbaum D; Pofahl M; Lavigne J; Liu Y; Theiss S; Slotta J; Escayg A; Dihné M; Beck H; Mantegazza M; Lerche H J. Neurosci. 2014 False 2 0
46572 Impaired action potential initiation in GABAergic interneurons causes hyperexcitable networks in an epileptic mouse model carrying a human Na(V)1.1 mutation. Hedrich UB; Liautard C; Kirschenbaum D; Pofahl M; Lavigne J; Liu Y; Theiss S; Slotta J; Escayg A; Dihné M; Beck H; Mantegazza M; Lerche H J. Neurosci. 2014 False 0 None