Article: Tau-mediated NMDA receptor impairment underlies dysfunction of a selectively vulnerable network in a mouse model of frontotemporal dementia.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Warmus BA; Sekar DR; McCutchen E; Schellenberg GD; Roberts RC; McMahon LL; Roberson ED J. Neurosci., 2014
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Nucleus accumbens medium spiny neuron | Ventral striatum neurons | input resistance (MΩ) | 132.4 (9) | 132.4 (MΩ) | Data Table |
Nucleus accumbens medium spiny neuron | Ventral striatum neurons | resting membrane potential (mV) | -80.9 (9) | -80.9 (mV) | Data Table |
Nucleus accumbens medium spiny neuron | Ventral striatum neurons | spike amplitude (mV) | 67.8 (9) | 67.8 (mV) | Data Table |
Nucleus accumbens medium spiny neuron | Ventral striatum neurons | spike half-width (ms) | 1.24 (9) | 1.24 (ms) | Data Table |
Nucleus accumbens medium spiny neuron | Ventral striatum neurons | spike max rise slope (mV/ms) | 105.8 (9) | 105.8 (mV/ms) | Data Table |
Nucleus accumbens medium spiny neuron | Ventral striatum neurons | spike threshold (mV) | -27.4 (9) | -27.4 (mV) | Data Table |
Metadata values
Experimental condition | Value |
---|---|
Species | Mice |
ElectrodeType | Patch-clamp |
RecTemp | 27.0 - 30.0 |
PrepType | in vitro |
InternalSolution | 5.0 |
internal_1_Mg | 5.0 |
internal_1_Cl | 10.0 |
internal_1_K | 120.0 |
ExternalSolution | 5.0 |
AnimalAge | 420.0 - 540.0 |
JxnPotential | Unreported |
Strain | C57BL |
internal_0_Mg | 5.0 |
internal_0_K | 120.0 |
internal_0_GTP | 0.3 |
internal_0_ATP | 2.0 |
internal_0_EGTA | 0.6 |
internal_0_HEPES | 20.0 |
internal_0_Cl | 10.0 |
external_0_Mg | 1.3 |
external_0_Na | 146.0 |
external_0_K | 2.5 |
external_0_Cl | 126.5 |
external_0_Ca | 2.5 |
external_0_glucose | 11.0 |
Data table listing
Data Table | Article Title | Authors | Journal | Year | Table needs expert? | Ephys table mentions | Curated by | Times validated |
---|---|---|---|---|---|---|---|---|
46631 | Tau-mediated NMDA receptor impairment underlies dysfunction of a selectively vulnerable network in a mouse model of frontotemporal dementia. | Warmus BA; Sekar DR; McCutchen E; Schellenberg GD; Roberts RC; McMahon LL; Roberson ED | J. Neurosci. | 2014 | False | 6 | Shreejoy Tripathy, Nathalie Binnion, | 1 |