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Article: Tau-mediated NMDA receptor impairment underlies dysfunction of a selectively vulnerable network in a mouse model of frontotemporal dementia.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Warmus BA; Sekar DR; McCutchen E; Schellenberg GD; Roberts RC; McMahon LL; Roberson ED
J. Neurosci., 2014

Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Nucleus accumbens medium spiny neuron Ventral striatum neurons input resistance (MΩ) 132.4 (9) 132.4 (MΩ) Data Table
Nucleus accumbens medium spiny neuron Ventral striatum neurons resting membrane potential (mV) -80.9 (9) -80.9 (mV) Data Table
Nucleus accumbens medium spiny neuron Ventral striatum neurons spike amplitude (mV) 67.8 (9) 67.8 (mV) Data Table
Nucleus accumbens medium spiny neuron Ventral striatum neurons spike half-width (ms) 1.24 (9) 1.24 (ms) Data Table
Nucleus accumbens medium spiny neuron Ventral striatum neurons spike max rise slope (mV/ms) 105.8 (9) 105.8 (mV/ms) Data Table
Nucleus accumbens medium spiny neuron Ventral striatum neurons spike threshold (mV) -27.4 (9) -27.4 (mV) Data Table

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Metadata values

Experimental condition Value
Species Mice
ElectrodeType Patch-clamp
RecTemp 27.0 - 30.0
PrepType in vitro
InternalSolution 5.0
internal_1_Mg 5.0
internal_1_Cl 10.0
internal_1_K 120.0
ExternalSolution 5.0
AnimalAge 420.0 - 540.0
JxnPotential Unreported
Strain C57BL
internal_0_Mg 5.0
internal_0_K 120.0
internal_0_GTP 0.3
internal_0_ATP 2.0
internal_0_EGTA 0.6
internal_0_HEPES 20.0
internal_0_Cl 10.0
external_0_Mg 1.3
external_0_Na 146.0
external_0_K 2.5
external_0_Cl 126.5
external_0_Ca 2.5
external_0_glucose 11.0

Data table listing

Data Table Article Title Authors Journal Year Table needs expert? Ephys table mentions Curated by Times validated
46631 Tau-mediated NMDA receptor impairment underlies dysfunction of a selectively vulnerable network in a mouse model of frontotemporal dementia. Warmus BA; Sekar DR; McCutchen E; Schellenberg GD; Roberts RC; McMahon LL; Roberson ED J. Neurosci. 2014 False 6 Shreejoy Tripathy, Nathalie Binnion, 1