n | Control 19/7 | KA-Treated 16/7 | Significant (Control vs. KA) |
---|---|---|---|
Duration, s | |||
GABA | 36.4 ± 3.7 | 56.7 ± 4.8 | 0.003 |
35.8 ± 6.7 | 52.3 ± 6.0 | 0.01 | |
NPA | 33.8 ± 3.4 | 47.8 ± 4.6 | 0.04 |
33.7 ± 6.5 | 52.3 ± 7.8 | 0.07 | |
Amplitude, mV | |||
GABA | 25.1 ± 2.0 | 29.3 ± 2.3 | |
27.1 ± 2.7 | 27.8 ± 6.0 | ||
NPA | 12.6 ± 2.1 | 9.6 ± 2.0 | |
12.7 ± 2.8 | 10.8 ± 2.8 | 0.04 | |
Conductance, % change | |||
GABA | 95.1 ± 1.7 | 91.2 ± 2.1 | |
94.1 ± 1.7 | 89.4 ± 2.8 | ||
NPA | 79.8 ± 3.4 | 57.0 ± 7.3 | 0.005 |
84.0 ± 2.5 | 60.4 ± 8.7 | 0.03 | |
Reversal potential, mV | |||
GABA | −47.6 ± 1.1 | −48.3 ± 1.6 | |
−48.3 ± 0.9 | −48.7 ± 2.5 | ||
NPA | −58.6 ± 1.8 | −60.2 ± 2.1 | |
−58.6 ± 2.2 | −59.9 ± 1.3 |
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Significant differences were found between control and epileptic animals for both the duration of GABA and nipecotic acid (NPA) responses and the conductance of the NPA responses.