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Article: GABA uptake and heterotransport are impaired in the dentate gyrus of epileptic rats and humans with temporal lobe sclerosis.

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Patrylo PR; Spencer DD; Williamson A
J. Neurophysiol., 2001


Table 3.

Characteristics of GABA and NPA responses in control and epileptic rats

n Control 19/7 KA-Treated 16/7 Significant (Control vs. KA)
Duration, s
 GABA 36.4  ±  3.7 56.7  ±  4.8 0.003
35.8  ±  6.7 52.3  ±  6.0 0.01
 NPA 33.8  ±  3.4 47.8  ±  4.6 0.04
33.7  ±  6.5 52.3  ±  7.8 0.07
Amplitude, mV
 GABA 25.1  ±  2.0 29.3  ±  2.3
27.1  ±  2.7 27.8  ±  6.0
 NPA 12.6  ±  2.1 9.6  ±  2.0
12.7  ±  2.8 10.8  ±  2.8 0.04
Conductance, % change
 GABA 95.1  ±  1.7 91.2  ±  2.1
94.1  ±  1.7 89.4  ±  2.8
 NPA 79.8  ±  3.4 57.0  ±  7.3 0.005
84.0  ±  2.5 60.4  ±  8.7 0.03
Reversal potential, mV
 GABA −47.6  ±  1.1 −48.3  ±  1.6
−48.3  ±  0.9 −48.7  ±  2.5
 NPA −58.6  ±  1.8 −60.2  ±  2.1
−58.6  ±  2.2 −59.9  ±  1.3
  • Significant differences were found between control and epileptic animals for both the duration of GABA and nipecotic acid (NPA) responses and the conductance of the NPA responses.


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