Table 5.
Characteristics of GABA and NPA responses in comparison and MTLE patients
| n | Comparison 13/7 | MTLE 17/9 | Significance (Comparison vs. MTLE) |
|---|---|---|---|
| Duration, s | |||
| GABA | 33.3 ± 6.3 | 59.4 ± 5.7 | 0.005 |
| 34.0 ± 9.1 | 57.8 ± 7.3 | 0.05 | |
| NPA | 31.5 ± 2.9 | 51.1 ± 3.3 | 0.002 |
| 35.9 ± 4.8 | 49.5 ± 3.7 | 0.04 | |
| Amplitude, mV | |||
| GABA | 16.3 ± 3.5 | 15.5 ± 2.2 | |
| 13.8 ± 5.0 | 13.3 ± 2.4 | ||
| NPA | 9.8 ± 3.2 | 1.9 ± 1.3 | 0.05 |
| 5.8 ± 4.5 | 2.24 ± 0.7 | 0.06 | |
| Conductance, % | |||
| GABA | 70.2 ± 5.5 | 75.2 ± 7.1 | |
| 76.8 ± 7.8 | 72.7 ± 10.6 | ||
| NPA | 71.2 ± 3.2 | 44.1 ± 6.2 | 0.001 |
| 69.0 ± 2.3 | 39.9 ± 10.0 | 0.03 | |
| Reversal, mV | |||
| GABA | −54.8 ± 4.0 | −54.2 ± 2.5 | |
| −56.6 ± 4.8 | −47.0 ± 3.7 | ||
| NPA | −61.5 ± 3.1 | −66.4 ± 3.1 | |
| −53.1 ± 15.3 | −65.5 ± 4.1 |
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The duration of both the GABA and NPA responses were significantly different in MTLE versus comparison granule cells. Additionally, significant differences were also noted for the NPA responses (percent conductance change and amplitude) between groups.