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Article: Serine/threonine protein phosphatases and synaptic inhibition regulate the expression of cholinergic-dependent plateau potentials.

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Fraser DD; Doll D; MacVicar BA
J. Neurophysiol., 2001


Table 1.

Membrane properties of CA1 pyramidal neurons following various pharmacological manipulations that abolished the cholinergic-dependent PP

rp, mV RIN, MΩ APAMP, mV APTH, mV APDUR, ms τ, ms n
Control −65 ± 0.3 146 ±  4 94 ± 1 −46 ± 0.4 1.6 ± 0.02 21.7 ± 0.6 110
GDP-β-S −58 ± 1.2 136 ± 10 101 ± 1 −40 ± 0.9 1.9 ± 0.07 16.9 ± 0.6 3
ATP-γ-S −65 ± 0.7 116 ± 11 93 ± 1 −47 ± 2.2 2.1 ± 0.09 19.7 ± 4.5 6
cal A −58 ± 1.5 152 ±  5 96 ± 2 −45 ± 1.8 1.9 ± 0.09 17.7 ± 1.2 9
OA −58 ± 1.7 143 ± 12 95 ± 2 −44 ± 1.2 1.8 ± 0.07 17.7 ± 0.7 6
m-LR −59 ± 3.5 137 ±  6 83 ± 6 −43 ± 1.7 1.7 ± 0.08 19.3 ± 1.4 6

  • Values are means ± SE; n is number of neurons. Input resistance (R IN) was calculated from a steady-state potential response, free of membrane rectification, to a hyperpolarizing current step. The membrane time constant (τ) was calculated as the time necessary to reach 1 −e −1 (63%) of the maximum voltage deflection. The action potential threshold (APTH) was measured as the membrane potential at the base of the action potential, whereas action potential amplitude (APAMP) was measured as the voltage difference between the threshold and peak amplitude. Action potential duration (APDUR) was measured at the threshold potential. rp, resting membrane potential; cal A, calyculin A; OA, okadaic acid; m-LR, microcystin-LR.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell Hippocampus CA1 cholinergic dependent plateau potentials pyramidal neurons resting membrane potential (mV) -65.0 ± 0.3 (110) -65.0 (mV) Data Table
Hippocampus CA1 pyramidal cell Hippocampus CA1 cholinergic dependent plateau potentials pyramidal neurons input resistance (MΩ) 146.0 ± 4.0 (110) 146.0 (MΩ) Data Table
Hippocampus CA1 pyramidal cell Hippocampus CA1 cholinergic dependent plateau potentials pyramidal neurons spike amplitude (mV) 94.0 ± 1.0 (110) 94.0 (mV) Data Table
Hippocampus CA1 pyramidal cell Hippocampus CA1 cholinergic dependent plateau potentials pyramidal neurons spike threshold (mV) -46.0 ± 0.4 (110) -46.0 (mV) Data Table
Hippocampus CA1 pyramidal cell Hippocampus CA1 cholinergic dependent plateau potentials pyramidal neurons spike width (ms) 1.6 ± 0.02 (110) 1.6 (ms) Data Table
Hippocampus CA1 pyramidal cell Hippocampus CA1 cholinergic dependent plateau potentials pyramidal neurons membrane time constant (ms) 21.7 ± 0.6 (110) 21.7 (ms) Data Table