Measurement | WT | Fmr1 KO2 | P valuec |
---|---|---|---|
Measurements were made by whole-cell recordings in WT (n = 12) and Fmr1 KO cells (n = 18).a Injected current required to evoke one spike (600 ms);b 600 ms current injection;c Student's unpaired t test; *mAHP, membrane afterhyperpolarization. | |||
Resting membrane potential (mV) | −65.6 ± 3.2 | 65.8 ± 2.9 | 0.82 |
Input resistance (MΩ) | 151 ± 63 | 155 ± 32 | 0.84 |
mAHP* amplitude (mV) | 6.3 ± 3.5 | 6.1 ± 3.2 | 0.93 |
Spike threshold (mV) | −49.0 ± 3.2 | −50.8 ± 3.1 | 0.13 |
Rheobase (Rh; pA)a | 70 ± 28 | 52 ± 28 | 0.1 |
Number of spikes at (Rh + 20 mV)b | 7.5 ± 4.5 | 7.5 ± 3.1 | 1 |
Article: Synaptic ionotropic glutamate receptors and plasticity are developmentally altered in the CA1 field of Fmr1 knockout mice.
Full Text (publisher's website) ; Article Metadata ; Article Data (extracted) Pilpel Y; Kolleker A; Berberich S; Ginger M; Frick A; Mientjes E; Oostra BA; Seeburg PH J. Physiol. (Lond.), 2009
Inferred neuron-electrophysiology data values
Neuron Type | Neuron Description | Ephys Prop | Extracted Value | Standardized Value | Content Source |
---|---|---|---|---|---|
Hippocampus CA1 pyramidal cell | AHP amplitude (mV) | 6.3 ± 3.5 (12) | 6.3 (mV) | Data Table | |
Hippocampus CA1 pyramidal cell | spike threshold (mV) | -49.0 ± 3.2 (12) | -49.0 (mV) | Data Table | |
Hippocampus CA1 pyramidal cell | rheobase | 70.0 ± 28.0 (12) | 70.0 (pA) | Data Table | |
Hippocampus CA1 pyramidal cell | resting membrane potential (mV) | -65.6 ± 3.2 (12) | -65.6 (mV) | Data Table | |
Hippocampus CA1 pyramidal cell | input resistance (MΩ) | 151.0 ± 63.0 (12) | 151.0 (MΩ) | Data Table |