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Article: Distinct electrophysiological properties of glutamatergic, cholinergic and GABAergic rat septohippocampal neurons: novel implications for hippocampal rhythmicity.

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Sotty F; Danik M; Manseau F; Laplante F; Quirion R; Williams S
J. Physiol. (Lond.), 2003


Table 1

Electrophysiological properties of chemically identified neuronal populations in the rat medial septum–diagonal band complex

Chemical phenotype ChAT-positive cells (n = 14) GAD67-positive cells (n = 24) ChAT- and GAD67-positive cells (n = 19) VGLUT-positive cells (n = 21)
Electrophysiological profile Slow-firing (n = 14) Burst-firing (n = 12) Fast-firing (n = 12) Burst-firing (n = 10) Fast-firing (n = 6) Slow-firing (n = 3) Slow/Cluster-firing (n = 21)
FMAX (HZ) 16.3 ± 1.6a, c 36.7 ± 5.5d, e, f, g 23.9 ± 4.1 28.3 ± 1.9l 23.6 ± 0.8 19.1 ± 5.9 18.6 ± 2.3
FSTEADY (Hz) 6.3 ± 0.6a, b, c 16.3 ± 2.4e, f, g 12.3 ± 1.6i 13.3 ± 2.7j, k, l 8.0 ± 1.2 5.5 ± 1.0 6.4 ± 0.7
Mean firing rate (Hz) 7.8 ± 0.6a, b, c 20.5 ± 2.4d, e, f, g 13.4 ± 1.9h, i 17.5 ± 2.2j, k, l 10.8 ± 0.8 7.5 ± 0.3 7.2 ± 0.7
AHP amplitude (mV) 7.4 ± 0.7c 5.1 ± 0.7f, g 6.6 ± 1.1i 4.2 ± 0.6j, k, l 6.99 ± 0.8 8.7 ± 1.2 7.7 ± 0.8
AHP duration (ms) 216.1 ± 15.3 169.0 ± 19.0f, g 190.9 ± 20.4 171.7 ± 34.3k, l 193.7 ± 17.9 250.0 ± 14.6 245.1 ± 29.7
Amplitude sag (mV) 3.0 ± 0.6a, b, c 11.2 ± 1.2d, e, f, g 6.6 ± 1.3h, i 10.6 ± 1.5j, k, l 6.11 ± 0.4 4.5 ± 1.8 2.76 ± 0.2
Amplitude Ih (pA) 29.4 ± 5.5a, c 54.3 ± 8.6f, g 42.6 ± 7.6 53.1 ± 10.9k, l 46.7 ± 9.8m 22.8 ± 7.8 28.0 ± 2.9
Ih activation (T1/2 ms) 431.1 ± 30.1a, b, c 212.6 ± 45.3f, g 326.0 ± 61.2i 245.6 ± 31.6k, l 243.5 ± 69.4m, n 495.7 ± 110.2 459.9 ± 25.6

  • Significant differences (P < 0.05) are indicated:

  • ↵a ChAT-positive slow-firing versus GAD-positive burst-firing cells

  • ↵b ChAT-positive slow-firing versus GAD-positive fast-firing cells

  • ↵c ChAT-positive slow-firing versus ChAT- and GAD-positive burst firing cells

  • ↵d GAD-positive burst firing versus GAD-positive fast-firing cells

  • ↵e GAD-positive burst firing versus ChAT and GAD fast-firing cells

  • ↵f GAD-positive burst-firing versus ChAT- and GAD-positive slow-firing cells

  • ↵g GAD-positive burst-firing versus VGLUT-positive slow/cluster-firing cells

  • ↵h GAD-positive fast-firing versus ChAT- and GAD-positive burst-firing cells

  • ↵i GAD-positive fast-firing versus VGLUT-positive slow/cluster-firing cells

  • ↵j ChAT- and GAD-positive burst-firing versus ChAT- and GAD-positive fast-firing cells

  • ↵k ChAT- and GAD-positive burst-firing versus ChAT- and GAD-positive slow-firing cells

  • ↵l ChAT- and GAD-positive burst-firing versus VGLUT-positive slow/cluster-firing cells

  • ↵m ChAT- and GAD-positive fast-firing versus ChAT- and GAD-positive slow-firing cells

  • ↵n ChAT- and GAD-positive fast-firing versus VGLUT-positive slow/cluster-firing cells.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Medial septum-diagonal band complex cholinergic ChAT-positive slow-firing neurons firing frequency (Hz) 7.8 ± 0.6 (14) 7.8 (Hz) Data Table
Other Medial septum-diagonal band complex GABAergic GAD67-positive burst-firing neurons firing frequency (Hz) 20.5 ± 2.4 (12) 20.5 (Hz) Data Table
Other Medial septum-diagonal band complex cholinergic ChAT-positive slow-firing neurons maximum firing rate 16.3 ± 1.6 (14) 16.3 (Hz) Data Table
Other Medial septum-diagonal band complex GABAergic GAD67-positive fast-firing neurons firing frequency (Hz) 13.4 ± 1.9 (12) 13.4 (Hz) Data Table
Other Medial septum-diagonal band complex ChAt-positive GAD67-positive burst-firing neurons firing frequency (Hz) 17.5 ± 2.2 (10) 17.5 (Hz) Data Table
Other Medial septum-diagonal band complex ChAt-positive GAD67-positive fast-firing neurons firing frequency (Hz) 10.8 ± 0.8 (6) 10.8 (Hz) Data Table
Other Medial septum-diagonal band complex ChAt-positive GAD67-positive slow-firing neurons firing frequency (Hz) 7.5 ± 0.3 (3) 7.5 (Hz) Data Table
Other Medial septum-diagonal band complex ChAt-negative GAD67-negative PAG-expressing VGLUT-positive slow/cluster-firing neurons firing frequency (Hz) 7.2 ± 0.7 (21) 7.2 (Hz) Data Table
Other Medial septum-diagonal band complex cholinergic ChAT-positive slow-firing neurons AHP amplitude (mV) 7.4 ± 0.7 (14) 7.4 (mV) Data Table
Other Medial septum-diagonal band complex GABAergic GAD67-positive burst-firing neurons AHP amplitude (mV) 5.1 ± 0.7 (12) 5.1 (mV) Data Table
Other Medial septum-diagonal band complex GABAergic GAD67-positive fast-firing neurons AHP amplitude (mV) 6.6 ± 1.1 (12) 6.6 (mV) Data Table
Other Medial septum-diagonal band complex ChAt-positive GAD67-positive burst-firing neurons AHP amplitude (mV) 4.2 ± 0.6 (10) 4.2 (mV) Data Table
Other Medial septum-diagonal band complex GABAergic GAD67-positive burst-firing neurons maximum firing rate 36.7 ± 5.5 (12) 36.7 (Hz) Data Table
Other Medial septum-diagonal band complex ChAt-positive GAD67-positive fast-firing neurons AHP amplitude (mV) 6.99 ± 0.8 (6) 6.99 (mV) Data Table
Other Medial septum-diagonal band complex ChAt-positive GAD67-positive slow-firing neurons AHP amplitude (mV) 8.7 ± 1.2 (3) 8.7 (mV) Data Table
Other Medial septum-diagonal band complex ChAt-negative GAD67-negative PAG-expressing VGLUT-positive slow/cluster-firing neurons AHP amplitude (mV) 7.7 ± 0.8 (21) 7.7 (mV) Data Table
Other Medial septum-diagonal band complex cholinergic ChAT-positive slow-firing neurons AHP duration (ms) 216.1 ± 15.3 (14) 216.1 (ms) Data Table
Other Medial septum-diagonal band complex GABAergic GAD67-positive burst-firing neurons AHP duration (ms) 169.0 ± 19.0 (12) 169.0 (ms) Data Table
Other Medial septum-diagonal band complex GABAergic GAD67-positive fast-firing neurons AHP duration (ms) 190.9 ± 20.4 (12) 190.9 (ms) Data Table
Other Medial septum-diagonal band complex ChAt-positive GAD67-positive burst-firing neurons AHP duration (ms) 171.7 ± 34.3 (10) 171.7 (ms) Data Table
Other Medial septum-diagonal band complex ChAt-positive GAD67-positive fast-firing neurons AHP duration (ms) 193.7 ± 17.9 (6) 193.7 (ms) Data Table
Other Medial septum-diagonal band complex ChAt-positive GAD67-positive slow-firing neurons AHP duration (ms) 250.0 ± 14.6 (3) 250.0 (ms) Data Table
Other Medial septum-diagonal band complex GABAergic GAD67-positive fast-firing neurons maximum firing rate 23.9 ± 4.1 (12) 23.9 (Hz) Data Table
Other Medial septum-diagonal band complex ChAt-negative GAD67-negative PAG-expressing VGLUT-positive slow/cluster-firing neurons AHP duration (ms) 245.1 ± 29.7 (21) 245.1 (ms) Data Table
Other Medial septum-diagonal band complex cholinergic ChAT-positive slow-firing neurons sag amplitude (mV) 3.0 ± 0.6 (14) 3.0 (mV) Data Table
Other Medial septum-diagonal band complex GABAergic GAD67-positive burst-firing neurons sag amplitude (mV) 11.2 ± 1.2 (12) 11.2 (mV) Data Table
Other Medial septum-diagonal band complex GABAergic GAD67-positive fast-firing neurons sag amplitude (mV) 6.6 ± 1.3 (12) 6.6 (mV) Data Table
Other Medial septum-diagonal band complex ChAt-positive GAD67-positive burst-firing neurons sag amplitude (mV) 10.6 ± 1.5 (10) 10.6 (mV) Data Table
Other Medial septum-diagonal band complex ChAt-positive GAD67-positive fast-firing neurons sag amplitude (mV) 6.11 ± 0.4 (6) 6.11 (mV) Data Table
Other Medial septum-diagonal band complex ChAt-positive GAD67-positive slow-firing neurons sag amplitude (mV) 4.5 ± 1.8 (3) 4.5 (mV) Data Table
Other Medial septum-diagonal band complex ChAt-negative GAD67-negative PAG-expressing VGLUT-positive slow/cluster-firing neurons sag amplitude (mV) 2.76 ± 0.2 (21) 2.76 (mV) Data Table
Other Medial septum-diagonal band complex ChAt-positive GAD67-positive burst-firing neurons maximum firing rate 28.3 ± 1.9 (10) 28.3 (Hz) Data Table
Other Medial septum-diagonal band complex ChAt-positive GAD67-positive fast-firing neurons maximum firing rate 23.6 ± 0.8 (6) 23.6 (Hz) Data Table
Other Medial septum-diagonal band complex ChAt-positive GAD67-positive slow-firing neurons maximum firing rate 19.1 ± 5.9 (3) 19.1 (Hz) Data Table
Other Medial septum-diagonal band complex ChAt-negative GAD67-negative PAG-expressing VGLUT-positive slow/cluster-firing neurons maximum firing rate 18.6 ± 2.3 (21) 18.6 (Hz) Data Table