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Article: Subclassified acutely dissociated cells of rat DRG: histochemistry and patterns of capsaicin-, proton-, and ATP-activated currents.

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Petruska JC; Napaporn J; Johnson RD; Gu JG; Cooper BY
J. Neurophysiol., 2000


Table 2.

Properties of subclassified cells

Cell Type
1 2 3 4 7
n 28 22 21 24 8
Cell properties
 Diameter, μm 24–30 25–32 18–22 33–40 16–22
 Size, pF 31.4  ±  1.1 31.5  ±  0.8 21.2  ±  1.3 56.8  ±  1.9 18.2  ±  1.3
 Input Resistance, MΩ 604.5  ±  57.6 726.7  ±  49.2 544.9  ±  66.9 297.1  ±  23.6 811.7  ±  127.4
 Membrane potential, mV −56.0  ±  0.4 −57.2  ±  0.7 −51.7  ±  1.3 −58.0  ±  1.0 −48.4  ±  1.9
Peak current
 Capsaicin, pA/pF 25.9  ±  6.6 134.9  ±  16.32-a 0.0 0.4  ±  0.1 4.25  ±  0.9
 Protons, pA/pF 5.6  ±  2.4 15.3  ±  2.72-b 127.0  ±  16.0 3.48  ±  0.4 45.8  ±  18.12-l
 ATP, pA/pF 13.3  ±  3.82-c * 51.7  ±  10.1 0.0 17.4  ±  3.5 2.9  ±  0.4
 αβ-methylene-ATP, pA/pF No test 44.6  ±  10.3 0.0 1.6  ±  0.5 No test
Action potential
 Duration, ms 7.35  ±  0.52-d 5.9  ±  0.12-e 3.5  ±  0.22-f 3.1  ±  0.12-g 6.5  ±  0.22-h
 Afterhyperpolarization, ms 57.0  ±  8.12-k 54.7  ±  7.62-k 17.5  ±  1.72-i 46.5  ±  5.52-k 110.2  ±  9.82-j
  • Values are means ± SE. Cell body properties, peak currents, and action potential features of subclassified cells are presented. The cases represent only those in which ATP, capsaicin, and protons were presented to the same cell. The order of presentation was counterbalanced. αβ-methylene-ATP was presented in a limited number of additional cases (type 2, n = 8; type 4,n = 5).

  • F2-a Significantly greater than all other cells.

  • F2-b Significantly greater than type 1.

  • F2-c Significantly greater than type 4.

  • F2-d Significantly greater than all other cells.

  • F2-e Significantly greater than types 3 and 4.

  • F2-f Significantly less than types 1, 2, and 7.

  • F2-g Significantly less than types 1, 2, and 7.

  • F2-h Significantly greater than types 3 and 4.

  • F2-i Significantly less than all other cells.

  • F2-j Significantly greater than all other cells.

  • F2-k Significantly greater than type 3 and significantly less than type 7.

  • F2-l Approached significance vs. type 3,P < 0.10. Statistics and probabilities are presented in the text. For protons and ATP-activated currents, statistical comparisons were only made between currents of similar form (i.e., desensitizing or non-desensitizing). * n = 6.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dorsal root ganglion cell resting membrane potential (mV) -56.0 ± 0.4 -56.0 (mV) Data Table
Dorsal root ganglion cell spike width (ms) 7.35 7.35 (ms) Data Table
Dorsal root ganglion cell AHP duration (ms) 57.0 57.0 (ms) Data Table
Dorsal root ganglion cell cell diameter (μm) 27.0 27.0 (um) Data Table
Dorsal root ganglion cell input resistance (MΩ) 604.5 ± 57.6 604.5 (MΩ) Data Table