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Article: Altered purinergic signaling in colorectal dorsal root ganglion neurons contributes to colorectal hypersensitivity.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Shinoda M; La JH; Bielefeldt K; Gebhart GF
J. Neurophysiol., 2010


Table 2.

Passive and active electrical properties of LS and TL colon neurons from zymosan-treated and control (saline-treated) mice

Property Treatment TL LS
A. Current injection
Whole cell capacitance, pF Control 33.0 ± 1.7 (37) 33.5 ± 1.3 (35)
Zymosan 28.9 ± 1.2 (25) 34.8 ± 1.3 (37)
Series resistance, mohm Control 6.0 ± 0.3 (37) 6.5 ± 0.3 (35)
Zymosan 6.3 ± 0.5 (25) 6.3 ± 0.3 (37)
Resting membrane potential, mV Control *−63.5 ± 1.4 (37) −64.3 ± 1.4 (35)*
Zymosan *−58.4 ± 1.9 (25) −57.9 ± 1.6 (37)*
Spontaneous activity (frequency) Control 0/37 0/35*
Zymosan 1/25 6/37*
AP threshold, mV Control −27.6 ± 1.2 (31) −28.9 ± 1.2 (24)
Zymosan −29.8 ± 1.3 (16) −29.4 ± 1.4 (26)
Rheobase, pA Control 247.3 ± 13.0 (37) 227.1 ± 21.7 (24)
Zymosan 237.5 ± 23.5 (16) 211.5 ± 16.5 (26)
AP@2× rheobase (frequency) Control 2.8 ± 0.8 (31) 4.4 ± 0.9 (23)
Zymosan 4.8 ± 1.4 (16) 5.4 ± 1.1 (26)
Input resistance, mohm Control −32.4 ± 3.6 (32) −40.1 ± 3.3 (26)
Zymosan −28.8 ± 3.8 (16) −35.9 ± 3.7 (26)
B. ATP (30 μM)
Number of cells which induce AP, % Control *2.9 (1/34) 5.7 (2/35)
Zymosan *20 (4/20) 16.8 (5/30)
Number of cells depolarized, % Control 50 (17/34) 52.6 (20/38)
Zymosan 75 (15/20) 67.7 (21/31)
Depolazation, mV Control 16.8 ± 2.7 (17) 13.9 ± 1.5 (20)
Zymosan 16.9 ± 1.7 (15) 17.1 ± 1.8 (21)
C. α,β-meATP (30 μM)
Number of cells which induce AP, % Control 0 (0/32) 0 (0/31)
Zymosan 10 (2/20) * 0 (0/25)
Number of cells depolarized, % Control 50 (16/32) 25.8 (8/31)*
Zymosan 70 (14/20) * 60 (15/25)*
Depolazation, mV Control 15.7 ± 2.0 (16) 9.5 ± 1.5 (8)
Zymosan 17.2 ± 1.7 (15) 11.3 ± 1.5 (15)
  • Values are means ± SE, or percentages. Number of neurons are in parentheses.

  • * P < 0.05. AP, action potential, ATP, adenosine-5′-triphosphate; α,β-meATP, α,β-m ethylene ATP.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Dorsal root ganglion cell thoracolumbar colorectal dorsal root ganglion cell rheobase (pA) 247.3 ± 13.0 247.3 (pA) Data Table
Dorsal root ganglion cell lumbosacral colorectal dorsal root ganglion cell rheobase (pA) 227.1 ± 21.7 227.1 (pA) Data Table
Dorsal root ganglion cell thoracolumbar colorectal dorsal root ganglion cell input resistance (mohm) -32.4 ± 3.6 -- Data Table
Dorsal root ganglion cell lumbosacral colorectal dorsal root ganglion cell input resistance (mohm) -40.1 ± 3.3 -- Data Table
Dorsal root ganglion cell thoracolumbar colorectal dorsal root ganglion cell cell capacitance (pF) 33.0 ± 1.7 33.0 (pF) Data Table
Dorsal root ganglion cell lumbosacral colorectal dorsal root ganglion cell cell capacitance (pF) 33.5 ± 1.3 33.5 (pF) Data Table
Dorsal root ganglion cell thoracolumbar colorectal dorsal root ganglion cell access resistance (mohm) 6.0 ± 0.3 6e-09 (MΩ) Data Table
Dorsal root ganglion cell lumbosacral colorectal dorsal root ganglion cell access resistance (mohm) 6.5 ± 0.3 6.5e-09 (MΩ) Data Table
Dorsal root ganglion cell thoracolumbar colorectal dorsal root ganglion cell resting membrane potential (mV) -63.5 ± 1.4 -63.5 (mV) Data Table
Dorsal root ganglion cell lumbosacral colorectal dorsal root ganglion cell resting membrane potential (mV) -64.3 ± 1.4 -64.3 (mV) Data Table
Dorsal root ganglion cell thoracolumbar colorectal dorsal root ganglion cell spike threshold (mV) -27.6 ± 1.2 -27.6 (mV) Data Table
Dorsal root ganglion cell lumbosacral colorectal dorsal root ganglion cell spike threshold (mV) -28.9 ± 1.2 -28.9 (mV) Data Table