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Article: Cocaine and kindling alter the sensitivity of group II and III metabotropic glutamate receptors in the central amygdala.

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Neugebauer V; Zinebi F; Russell R; Gallagher JP; Shinnick-Gallagher P
J. Neurophysiol., 2000


Table 1.

Chronic cocaine treatment and kindling in vivo alter membrane properties and/or synaptic transmission in central amygdala neurons recorded in vitro

Control Neurons Chronic Cocaine Neurons Kindled Neurons
Resting membrane potential, mV −59.0  ±  0.4 (59) −64.9  ±  1.6 (23) −60.5 ± 1.2 (22)
Input resistance, MΩ 104.6  ±  5.1 (51) 84.8  ±  4.9 (19) 105.2 ± 5.7 (15)
Slope conductance, nS 8.5  ±  0.3 (42) 12.0  ±  0.5 (17) 9.1 ± 0.42 (20)
Synapse
 VAP-CeA
  EPSC threshold V 8.1  ±  0.9 (38) 4.9  ±  1.1 (23) 7.8 ± 1.1 (21)
  Spike threshold V 18.9  ±  1.0 (38) 14.2  ±  1.9 (23) 14.8 ± 0.9 (22)
 BLA-CeA
  EPSC threshold V 7.1  ±  0.8 (38) 3.8  ±  0.9 (23) 6.5 ± 1.0 (21)
  Spike threshold V 17.2  ±  1.3 (38) 14.1  ±  1.8 (23) 12.4 ± 1.3 (22)
  • Values are means ± SE. Parentheses enclose number of neurons. Control neurons are comprised of naı̈ve control, saline-injected, and implanted, nonstimulated. † P < 0.05; ‡ P < 0.01; compared to control neurons, one-way ANOVA followed by Dunnett's multiple comparison test. VAP, ventral amygdaloid pathway; CeA, central amygdala; BLA, basolateral amygdala; EPSC, excitatory postsynaptic current.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Central amygdala neurons resting membrane potential (mV) -59.0 ± 0.4 (59) -59.0 (mV) Data Table
Other Central amygdala neurons input resistance (MΩ) 104.6 ± 5.1 (51) 104.6 (MΩ) Data Table