Control Neurons | Chronic Cocaine Neurons | Kindled Neurons | |
---|---|---|---|
Resting membrane potential, mV | −59.0 ± 0.4 (59) | −64.9 ± 1.6‡ (23) | −60.5 ± 1.2 (22) |
Input resistance, MΩ | 104.6 ± 5.1 (51) | 84.8 ± 4.9† (19) | 105.2 ± 5.7 (15) |
Slope conductance, nS | 8.5 ± 0.3 (42) | 12.0 ± 0.5‡ (17) | 9.1 ± 0.42 (20) |
Synapse | |||
VAP-CeA | |||
EPSC threshold V | 8.1 ± 0.9 (38) | 4.9 ± 1.1† (23) | 7.8 ± 1.1 (21) |
Spike threshold V | 18.9 ± 1.0 (38) | 14.2 ± 1.9† (23) | 14.8 ± 0.9† (22) |
BLA-CeA | |||
EPSC threshold V | 7.1 ± 0.8 (38) | 3.8 ± 0.9† (23) | 6.5 ± 1.0 (21) |
Spike threshold V | 17.2 ± 1.3 (38) | 14.1 ± 1.8 (23) | 12.4 ± 1.3† (22) |
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Values are means ± SE. Parentheses enclose number of neurons. Control neurons are comprised of naı̈ve control, saline-injected, and implanted, nonstimulated. † P < 0.05; ‡ P < 0.01; compared to control neurons, one-way ANOVA followed by Dunnett's multiple comparison test. VAP, ventral amygdaloid pathway; CeA, central amygdala; BLA, basolateral amygdala; EPSC, excitatory postsynaptic current.