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Article: Cocaine and kindling alter the sensitivity of group II and III metabotropic glutamate receptors in the central amygdala.

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Neugebauer V; Zinebi F; Russell R; Gallagher JP; Shinnick-Gallagher P
J. Neurophysiol., 2000


Table 2.

Summary of mGluR agonists ED50 s in control, kindled, and chronic cocaine-treated animals

LA-BLA,* nM BLA-CeA, nM VAP-CeA, nM
LCCG1
 Control/implanted 36 65.8 157.6
 Kindled 1.2 32.8 13.9
LCCG1
 Control/saline 57.8 719
 Chronic cocaine (NE) (NE)
LY354740
 Control/saline 2.1 27.7
 Chronic cocaine (NE) (NE)
LAP4
 Control/implanted 297 54.8 17.6
 Kindled 10.8 1.1 3.7
LAP4
 Control/saline 80.7 15.3
 Chronic cocaine (NE) (NE)

  • ↵*  Data from Neugebauer et al. (1997). NE, no effect; LA, lateral amygdala; mGluR, metabotropic glutamate receptor; LCCG1, (2S,1′S,2′S)-2-(carboxycyclopropyl)glycine; LY354740, (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid; LAP4, L(+)-2-amino-4-phosphonobutyrate.


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