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Article: Enhanced intrinsic excitability and EPSP-spike coupling accompany enriched environment-induced facilitation of LTP in hippocampal CA1 pyramidal neurons.

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Malik R; Chattarji S
J. Neurophysiol., 2012


Table 1.

Summary of passive and active membrane properties of CA1 neurons from control and enriched rats

CON EE
Parameters Mean ± SE n Mean ± SE n P value
Resting membrane potential (mV) −64.8 ± 0.8 16 −66.4 ± 0.5 16 0.1
Input resistance (MΩ) 100.6 ± 3.8 16 105.3 ± 4.4 16 0.5
Membrane time constant (ms) 27.9 ± 1 16 31.2 ± 1.7 16 0.1
AHP (mV) 2.7 ± 0.2 16 1.9 ± 0.2 16 0.009*
ADP (mV) 16.2 ± 0.4 16 15.8 ± 0.5 16 0.1
AP amplitude (mV) 120.1 ± 1.1 16 118.8 ± 1.2 16 0.45
AP half-width (ms) 1.6 ± 0.02 16 1.6 ± 0.04 16 0.6
AP threshold (mV) −51.5 ± 1.1 16 −55.5 ± 1.3 16 0.02†
Max. dV/dt (KV/s) 0.42 ± 0.001 16 0.42 ± 0.001 16 0.9
Current threshold (nA) 0.7 ± 0.03 16 0.56 ± 0.03 16 0.008*
Sag voltage (mV) 13.3 ± 0.3 16 12.7 ± 0.5 16 0.6
Resonance frequency (Hz) 1.7 ± 0.2 11 2 ± 0.2 14 0.14

  • The CA1 neurons in the environmental enrichment (EE) group have decreased- after-hyperpolarization potential (AHP) amplitude and have a reduced action potential (AP) threshold. CON, control (routine animal maintenance procedures); ADP, after-depolarization potential; Max. dV/dt, maximum first derivative of the voltage response.

  • ↵* P < 0.01;

  • ↵† P < 0.05, Student's t-test.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Hippocampus CA1 pyramidal cell membrane time constant (ms) 27.9 ± 1.0 (16) 27.9 (ms) Data Table
Hippocampus CA1 pyramidal cell resting membrane potential (mV) -64.8 ± 0.8 (16) -64.8 (mV) Data Table
Hippocampus CA1 pyramidal cell AHP amplitude (mV) 2.7 ± 0.2 (16) 2.7 (mV) Data Table
Hippocampus CA1 pyramidal cell ADP amplitude (mV) 16.2 ± 0.4 (16) 16.2 (mV) Data Table
Hippocampus CA1 pyramidal cell spike amplitude from resting (mV) 120.1 ± 1.1 (16) 106.8 (mV) Data Table
Hippocampus CA1 pyramidal cell spike half-width (ms) 1.6 ± 0.02 (16) 1.6 (ms) Data Table
Hippocampus CA1 pyramidal cell spike threshold (mV) -51.5 ± 1.1 (16) -51.5 (mV) Data Table
Hippocampus CA1 pyramidal cell spike max rise slope 0.42 ± 0.001 (16) 0.42 (mV/ms) Data Table
Hippocampus CA1 pyramidal cell rheobase (nA) 0.7 ± 0.03 (16) 700.0 (pA) Data Table
Hippocampus CA1 pyramidal cell sag amplitude (mV) 13.3 ± 0.3 (16) 13.3 (mV) Data Table
Hippocampus CA1 pyramidal cell input resistance (MΩ) 100.6 ± 3.8 (16) 100.6 (MΩ) Data Table