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Article: Altered purinergic signaling in colorectal dorsal root ganglion neurons contributes to colorectal hypersensitivity.

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Shinoda M; La JH; Bielefeldt K; Gebhart GF
J. Neurophysiol., 2010


Table 3.

Current kinetics for LS and TL colon sensory neurons from saline- and zymosan-treated mice

ATP (100 μM) α,β-meATP (100 μM)
Current Treatment 10–80% Rise Time, ms tau. ms Current Density, pA/pF 10–80% Rise Time, ms tau. ms Current Density, pA/pF
LS
    Fast Saline 36.4 ± 6.5 96.8 ± 15.4 15.5 ± 3.1 27.3 ± 6.2 94.8 ± 20.6 21.9 ± 3.0
Zymosan 49.1 ± 9.9 127.7 ± 9.5 13.8 ± 3.2 30.1 ± 4.4 77.2 ± 10.5 22.0 ± 3.3
    Slow Saline 224.1 ± 29.4 N/A 18.7 ± 4.6 258.5 ± 11.0 N/A 16.3 ± 3.9
Zymosan 281.1 ± 36.3 N/A 20.1 ± 4.7 264.9 ± 22.8 N/A 17.3 ± 3.6
TL
    Fast Saline 53.5 ± 11.0 100.1 ± 15.7 17.3 ± 2.6 44.6 ± 7.2 84.1 ± 8.9 20.5 ± 2.9
Zymosan 68.8 ± 9.4 110.1 ± 9.7 17.4 ± 3.3 34.9 ± 4.6 83.4 ± 6.6 24.0 ± 2.0
    Slow Saline 220.6 ± 31.1 N/A 25.0 ± 4.0 358.0 ± 54.0 N/A 13.7 ± 8.6
Zymosan 224.6 ± 25.6 N/A 33.4 ± 10.4 349.1 ± 26.0 N/A 16.2 ± 3.4

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Inferred neuron-electrophysiology data values

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