Rise and decay time constants of NMDAR currents in WT and GlyT1+/− CA1 pyramidal cells recorded in the absence and presence
of glycine at −70 mV
Low Mg 2+ ACSF* (–Glycine)
Values are mean ±
*Electrically evoked NMDAR currents were recorded in a low Mg2+ ACSF (0.1 mm) in the presence of NBQX (20 μm), picrotoxin (50 μm), CGP 52432 (10 μm) and strychnine (0.5 μm). The fast and slow decay components are designated τf and τs, the weighted time constant by τmean. † Electrically evoked NMDAR currents recorded in low Mg2+ ACSF as in * plus glycine (10μm); ‡Significant difference between WT and GlyT1+/− mice (P < 0.05).