Article: Reduced glycine transporter type 1 expression leads to major changes in glutamatergic neurotransmission of CA1 hippocampal neurones in mice.

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Martina M; B-Turcotte ME; Halman S; Tsai G; Tiberi M; Coyle JT; Bergeron R
J. Physiol. (Lond.), 2005

Table 1.

Rise and decay time constants of NMDAR currents in WT and GlyT1+/− CA1 pyramidal cells recorded in the absence and presence of glycine at −70 mV

−70 mV	Low Mg ²⁺ ACSF* (–Glycine)				+Glycine†
	Activation	Deactivation			Activation	Deactivation
	τ_act (ms)	τ_f‡ (ms)	τ_s‡ (ms)	τ_mean‡ (ms)	τ_act (ms)	τ_f (ms)	τ_s (ms)	τ_mean‡ (ms)
Values are mean ± s.e.m. Electrically evoked NMDAR currents were recorded in a low Mg²⁺ ACSF (0.1 mm) in the presence of NBQX (20 μm), picrotoxin (50 μm), CGP 52432 (10 μm) and strychnine (0.5 μm). The fast and slow decay components are designated τ_f and τ_s, the weighted time constant by τ_mean. † Electrically evoked NMDAR currents recorded in low Mg²⁺ ACSF as in plus glycine (10μm); ‡Significant difference between WT and GlyT1+/− mice (P < 0.05).
WT	7.44 ± 0.6	56.73 ± 3.91	433.02 ± 66.02	142.48 ± 20.83	9.97 ± 0.86	67.68 ± 7.55	512.65 ± 42.46	182.65 ± 42.09
	n = 27	n = 27	n = 27	n = 27	n = 5	n = 5	n = 5	n = 5
GlyT1+/−	8.01 ± 0.9	38.79 ± 4.12	232.73 ± 23.95	95.41 ± 5.98	9.21 ± 1.76	43.12 ± 7.27	257.18 ± 37.48	102.71 ± 6.41
	n = 35	n = 35	n = 35	n = 35	n = 13	n = 13	n = 13	n = 13

Inferred neuron-electrophysiology data values

Neuron Type	Neuron Description	Ephys Prop	Extracted Value	Standardized Value	Content Source