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Article: Regulation of action potential size and excitability in substantia nigra compacta neurons: sensitivity to 4-aminopyridine.

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Nedergaard S
J. Neurophysiol., 1999


Table 1.

Characteristics of spontaneous APs

Control APs Variable APs
Threshold, mV −39.7  ±  0.8 −52.2  ±  1.0*
Overshoot, mV 33.6  ±  0.9 30.1  ±  1.7
Half width, ms 1.22  ±  0.05 0.77  ±  0.05*
Rate of rise, V · s−1 193  ±  8 218  ±  12
Rate of fall, V · s−1 44  ±  2 66  ±  5*
Ratio of rate of rise to rate of fall 4.6  ±  0.2 3.5  ±  0.3
fAHP peak, mV −67.4  ±  0.9 −69.7  ±  1.1
sAHP peak, mV −71.0  ±  1.1
  • Values are means ± SE. Measurements were made on individual spontaneous APs generated at low frequency (0.2–1.0 Hz). The APs were selected from each cell on the basis of the threshold, being either close to the average (control APs; n = 35), or >8.0 mV negative to the average (variable APs; n = 18). AP, action potential; fAHP and sAHP, fast and slow afterhyperpolarization, respectively. *P < 0.001. †P < 0.05. ‡P < 0.01.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Substantia nigra pars compacta dopaminergic cell spike max rise slope 193.0 ± 8.0 (35) 193.0 (mV/ms) Data Table
Substantia nigra pars compacta dopaminergic cell spike max decay slope 44.0 ± 2.0 (35) 44.0 (mV/ms) Data Table
Substantia nigra pars compacta dopaminergic cell spike threshold (mV) -39.7 ± 0.8 (35) -39.7 (mV) Data Table
Substantia nigra pars compacta dopaminergic cell fast AHP voltage (mV) -67.4 ± 0.9 (35) -67.4 (mV) Data Table
Substantia nigra pars compacta dopaminergic cell slow AHP duration (mV) -71.0 ± 1.1 (35) 31.3 (ms) Data Table
Substantia nigra pars compacta dopaminergic cell spike peak (mV) 33.6 ± 0.9 (35) 33.6 (mV) Data Table
Substantia nigra pars compacta dopaminergic cell spike half-width (ms) 1.22 ± 0.05 (35) 1.22 (ms) Data Table