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Article: Ionic mechanism of electroresponsiveness in cerebellar granule cells implicates the action of a persistent sodium current.

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D'Angelo E; De Filippi G; Rossi P; Taglietti V
J. Neurophysiol., 1998


Table 1.

Action potential properties in rat cerebellar granule cells

n Overshoot Undershoot HW Rising Rate Falling Rate dV/dt
Ratio
Bridge PPR 6 12.4 ± 9.2 −56.4 ± 9.7 0.65 ± 0.26 196 ± 106 −128.3 ± 67.2 1.53
Patch-clamp fast PPR 10 9.8 ± 11 −55.0 ± 4.6 0.79 ± 0.16 151.1 ± 54.6 −94.5 ± 33.9 1.59
Patch-clamp fast WCR 8 11.6 ± 8.5 −53.6 ± 5.4 0.92 ± 0.29 155.3 ± 27.9 −88.8 ± 29.9 1.74

  • Values are means ± SD. The overshoot, undershoot, and rising and falling rate of granule cell spikes were compared in different recording conditions. Recordings obtained using a bridge amplifier did not significantly differ from those obtained using a patch-clamp amplifier in the fast current-clamp mode. In the fast patch-clamp current-clamp mode, no significant difference was observed between the perforated-patch (PPR) and whole cell recording (WCR) configuration. Statistical significance has been tested at the 0.05 probability level.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Cerebellum granule cell spike peak 9.8 ± 11.0 (10) 9.8 (mV) Data Table
Cerebellum granule cell AHP voltage -55.0 ± 4.6 (10) -55.0 (mV) Data Table
Cerebellum granule cell spike half-width 0.79 ± 0.16 (10) 0.79 (ms) Data Table
Cerebellum granule cell spike max rise slope 151.1 ± 54.6 (10) 151.1 (mV/ms) Data Table
Cerebellum granule cell spike max decay slope -94.5 ± 33.9 (10) 94.5 (mV/ms) Data Table
Cerebellum granule cell spike peak 11.6 ± 8.5 (8) 11.6 (mV) Data Table
Cerebellum granule cell AHP voltage -53.6 ± 5.4 (8) -53.6 (mV) Data Table
Cerebellum granule cell spike half-width 0.92 ± 0.29 (8) 0.92 (ms) Data Table
Cerebellum granule cell spike max rise slope 155.3 ± 27.9 (8) 155.3 (mV/ms) Data Table
Cerebellum granule cell spike max decay slope -88.8 ± 29.9 (8) 88.8 (mV/ms) Data Table