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Article: Modulatory actions of dopamine on NMDA receptor-mediated responses are reduced in D1A-deficient mutant mice.

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Levine MS; Altemus KL; Cepeda C; Cromwell HC; Crawford C; Ariano MA; Drago J; Sibley DR; Westphal H
J. Neurosci., 1996


Table 2.

Modulation of responses mediated by activation of NMDA receptors

A. Mean percentage change

D1agonist DA
Amplitude Duration Area Amplitude Duration Area
Control 39  ± 14 (n  = 13)3_a 22  ± 7 72  ± 21 83  ± 18 (n  = 23) 37  ± 12 149  ± 29
Mutant −2  ± 3 (n = 19)b 5  ± 43_b 5  ± 53_b 25  ± 13 (n  = 21)3_b −2  ± 43_b 23  ± 193_b

  • ↵F3_a Mean + SE. Number for each group is in parentheses. Values are percentage change with respect to baseline. Data in A and B are pooled for responses evoked by iontophoretic application of NMDA and from DPSPs.

  • ↵F3_b Differences between mean values for D1 agonists and DA for controls and mutants are statistically significant (D1 agonists: t = 3.5, df = 30, p = 0.0015 for amplitude; t = 2.40, df = 31, p = 0.0226 for duration; t = 3.69, df = 30,p = 0.0009 for area; DA: t = 2.52, df = 40,p = 0.0155 for amplitude; t = 3.00, df = 40,p = 0.0047 for duration; t = 3.43, df = 40,p = 0.0014 for area).


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