Table 2.
Effects of blockers on mAHP and sAHP amplitudes after 10 spikes at 100 Hz
| mAHP, mV | sAHP, mV | |
|---|---|---|
| Control | 9.1 ± 4 (9) | 3.6 ± 1 (9) |
| Nifedipine (5 μM) | 8.6 ± 4 (9) | 3.5 ± 1 (9) |
| Control | 10.5 ± 1 (10) | 3.0 ± 0 (10) |
| CgTx (1 μM) | 10.0 ± 1 (10) | 1.2 ± 0 (10)* |
| Control | 9.4 ± 1 (13) | 3.3 ± 0 (13) |
| AgTx (25 nM) | 7.3 ± 1 (13)* | 1.4 ± 0 (13)* |
| Control | 11.0 ± 1 (10) | 3.3 ± 0 (10) |
| AgTx (25 nM) | 9.5 ± 1 (10) | 1.5 ± 0 (10)* |
| AgTx plus CgTx | 9.4 ± 1 (10) | 1.1 ± 0 (10)* |
| Control | 12.4 ± 1 (6) | 3.3 ± 0 (6) |
| AgTx plus CgTx | 10.4 ± 1 (6)* | 1.0 ± 0 (6)* |
| AgTx + CgTx + MVIIC | 8.1 ± 2 (6)* | 0.2 ± 0 (6)*† |
| Control | 8.6 ± 1 (12) | 3.3 ± 1 (12) |
| All Inorganics | 4.1 ± 1 (12)* | 0.3 ± 0 (12)* |
-
Values are means ± SE (with number of neurons in parentheses). CgTx, ω-conotoxin GVIA (1 μM); AgTx, ω-agatoxin IVA (25 nM); MVIIC, ω-conotoxin MVIIC (2 μM). * Statistically significant value from control (α ≤ 0.05, Wilcoxon signed rank test). †, statistically significant value from AgTx + CgTx (α ≤ 0.05, Wilcoxon signed rank test). All Inorganics, combined data from Co2+ (6 cells), Cd2+ (4 cells), and Mn2+ (2 cells).