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Article: Intrinsic membrane characteristics distinguish two subsets of nociceptive modulatory neurons in rat RVM.

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Zagon A; Meng X; Fields HL
J. Neurophysiol., 1997


Table 1.

Electrophysiological and morphological properties in functionally identified cell groups

Fast-Spike Cells Slow-Spike Cells
on off on off neutral
Resting potential, mV  60 ± 1.8  59 ± 2.1  64 ± 2.7  67 ± 4.3  65 ± 2.8
Input resistance, MΩ  18 ± 2  29 ± 4  34 ± 6  38 ± 9  23 ± 3
Discharge threshold, mV  58 ± 1.5  58 ± 2.0  62 ± 2.0  66 ± 4.0  64 ± 2.6
Spike parameters
Spike amplitude, mV  56 ± 2.3  54 ± 2.3  63 ± 3.3  74 ± 5.5  66 ± 2.3
Spike width,* ms 0.27 ± 0.01 0.26 ± 0.02 0.38 ± 0.02 0.40 ± 0.05 0.5 ± 0.03
Max. depolarization, V/s  280 ± 16  287 ± 27  275 ± 20  344 ± 24  281 ± 21
Max. repolarization, V/s  270 ± 13  287 ± 29  206 ± 12  191 ± 78  180 ± 18
Ratio of de-repolarization 1.0 ± 0.03 1.0 ± 0.02 1.4 ± 0.05 1.8 ± 0.14 1.6 ± 0.16
Latency to first AHP, ms 0.6 ± 0.02 0.6 ± 0.1 2.8 ± 0.3 3.6 ± 0.3 2.5 ± 0.4
Amplitude of AHP, mV 5.9 ± 0.7 5.9 ± 1.0 11.2 ± 1.6 15.6 ± 1.3 11.3 ± 0.9
Morphology (note lower cell counts), μm
Long soma axis  42 ± 2.5  23 ± 1.7  27 ± 1.5 28  30 ± 1.0
Short soma axis  26 ± 1.9  15 ± 1.6  16 ± 2.1 24  14 ± 1.7
Primary dendrite diameter 5.6 ± 0.6 2.6 ± 0.2 2.0 ± 0 3.5 2.6 ± 0.2
(n = 5) (n = 5) (n = 3†) (n = 1) (n = 5†)

  • Values are means ± SE; number of events for fast-spike (FS) on cells was 20, for FS off cells was 10, for slow-spike (SS) on cells was 7, for SS off cells was 5, and for SS neutral cells was 13. AHP, afterhyperpolarization.

  • * Measured at half amplitude.

  • † The number refers to cells where the quality of intracellular labeling was suitable for morphological measurements.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Other Rostral ventromedial medulla fast-spiking off-response neurons input resistance (MΩ) 29.0 ± 4.0 (5) 29.0 (MΩ) Data Table
Other Rostral ventromedial medulla slow-spiking on-response neurons input resistance (MΩ) 34.0 ± 6.0 (3) 34.0 (MΩ) Data Table
Other rostral ventromedial medulla slow-spiking off -response neurons input resistance (MΩ) 38.0 ± 9.0 (1) 38.0 (MΩ) Data Table
Other Rostral ventromedial medulla neutral slow-spiking inhibitory neurons input resistance (MΩ) 23.0 ± 3.0 (5) 23.0 (MΩ) Data Table
Other Rostral ventromedial medulla fast-spiking on-response neurons spike threshold (mV) 58.0 ± 1.5 (5) -58.0 (mV) Data Table
Other Rostral ventromedial medulla fast-spiking off-response neurons spike threshold (mV) 58.0 ± 2.0 (5) -58.0 (mV) Data Table
Other Rostral ventromedial medulla slow-spiking on-response neurons spike threshold (mV) 62.0 ± 2.0 (3) -62.0 (mV) Data Table
Other rostral ventromedial medulla slow-spiking off -response neurons spike threshold (mV) 66.0 ± 4.0 (1) -66.0 (mV) Data Table
Other Rostral ventromedial medulla neutral slow-spiking inhibitory neurons spike threshold (mV) 64.0 ± 2.6 (5) -64.0 (mV) Data Table
Other Rostral ventromedial medulla fast-spiking on-response neurons spike amplitude (mV) 56.0 ± 2.3 (5) 56.0 (mV) Data Table
Other Rostral ventromedial medulla fast-spiking off-response neurons spike amplitude (mV) 54.0 ± 2.3 (5) 54.0 (mV) Data Table
Other Rostral ventromedial medulla slow-spiking on-response neurons spike amplitude (mV) 63.0 ± 3.3 (3) 63.0 (mV) Data Table
Other rostral ventromedial medulla slow-spiking off -response neurons spike amplitude (mV) 74.0 ± 5.5 (1) 74.0 (mV) Data Table
Other Rostral ventromedial medulla neutral slow-spiking inhibitory neurons spike amplitude (mV) 66.0 ± 2.3 (5) 66.0 (mV) Data Table
Other Rostral ventromedial medulla fast-spiking on-response neurons spike half-width (* ms) 0.27 ± 0.01 (5) 0.27 (ms) Data Table
Other Rostral ventromedial medulla fast-spiking off-response neurons spike half-width (* ms) 0.26 ± 0.02 (5) 0.26 (ms) Data Table
Other Rostral ventromedial medulla fast-spiking on-response neurons resting membrane potential (mV) 60.0 ± 1.8 (5) -60.0 (mV) Data Table
Other Rostral ventromedial medulla slow-spiking on-response neurons spike half-width (* ms) 0.38 ± 0.02 (3) 0.38 (ms) Data Table
Other rostral ventromedial medulla slow-spiking off -response neurons spike half-width (* ms) 0.4 ± 0.05 (1) 0.4 (ms) Data Table
Other Rostral ventromedial medulla neutral slow-spiking inhibitory neurons spike half-width (* ms) 0.5 ± 0.03 (5) 0.5 (ms) Data Table
Other Rostral ventromedial medulla fast-spiking on-response neurons spike max rise slope (V/s) 280.0 ± 16.0 (5) 280.0 (mV/ms) Data Table
Other Rostral ventromedial medulla fast-spiking off-response neurons spike max rise slope (V/s) 287.0 ± 27.0 (5) 287.0 (mV/ms) Data Table
Other Rostral ventromedial medulla slow-spiking on-response neurons spike max rise slope (V/s) 275.0 ± 20.0 (3) 275.0 (mV/ms) Data Table
Other rostral ventromedial medulla slow-spiking off -response neurons spike max rise slope (V/s) 344.0 ± 24.0 (1) 344.0 (mV/ms) Data Table
Other Rostral ventromedial medulla neutral slow-spiking inhibitory neurons spike max rise slope (V/s) 281.0 ± 21.0 (5) 281.0 (mV/ms) Data Table
Other Rostral ventromedial medulla fast-spiking off-response neurons resting membrane potential (mV) 59.0 ± 2.1 (5) -59.0 (mV) Data Table
Other Rostral ventromedial medulla fast-spiking on-response neurons spike max decay slope (V/s) 270.0 ± 13.0 (5) 270.0 (mV/ms) Data Table
Other Rostral ventromedial medulla fast-spiking off-response neurons spike max decay slope (V/s) 287.0 ± 29.0 (5) 287.0 (mV/ms) Data Table
Other Rostral ventromedial medulla slow-spiking on-response neurons spike max decay slope (V/s) 206.0 ± 12.0 (3) 206.0 (mV/ms) Data Table
Other rostral ventromedial medulla slow-spiking off -response neurons spike max decay slope (V/s) 191.0 ± 78.0 (1) 191.0 (mV/ms) Data Table
Other Rostral ventromedial medulla neutral slow-spiking inhibitory neurons spike max decay slope (V/s) 180.0 ± 18.0 (5) 180.0 (mV/ms) Data Table
Other Rostral ventromedial medulla slow-spiking on-response neurons resting membrane potential (mV) 64.0 ± 2.7 (3) -64.0 (mV) Data Table
Other Rostral ventromedial medulla fast-spiking on-response neurons AHP amplitude (mV) 5.9 ± 0.7 (5) 5.9 (mV) Data Table
Other Rostral ventromedial medulla fast-spiking off-response neurons AHP amplitude (mV) 5.9 ± 1.0 (5) 5.9 (mV) Data Table
Other rostral ventromedial medulla slow-spiking off -response neurons resting membrane potential (mV) 67.0 ± 4.3 (1) -67.0 (mV) Data Table
Other Rostral ventromedial medulla slow-spiking on-response neurons AHP amplitude (mV) 11.2 ± 1.6 (3) 11.2 (mV) Data Table
Other rostral ventromedial medulla slow-spiking off -response neurons AHP amplitude (mV) 15.6 ± 1.3 (1) 15.6 (mV) Data Table
Other Rostral ventromedial medulla neutral slow-spiking inhibitory neurons AHP amplitude (mV) 11.3 ± 0.9 (5) 11.3 (mV) Data Table
Other Rostral ventromedial medulla neutral slow-spiking inhibitory neurons resting membrane potential (mV) 65.0 ± 2.8 (5) -65.0 (mV) Data Table
Other Rostral ventromedial medulla fast-spiking on-response neurons input resistance (MΩ) 18.0 ± 2.0 (5) 18.0 (MΩ) Data Table