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Article: Motor neuron rescue in spinal muscular atrophy mice demonstrates that sensory-motor defects are a consequence, not a cause, of motor neuron dysfunction.

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Gogliotti RG; Quinlan KA; Barlow CB; Heier CR; Heckman CJ; Didonato CJ
J. Neurosci., 2012


Table 1.

Spinal motor neuron gem counts

Group ID Genotype Avg. gems per cell MNs counted MNs with gems % MNs with gems Number of cells with N
0 Gems 1 Gem 2 Gems 3 Gems
Control SMN2+/−, Smn2B-Neo/+ 1.07 ± 0.19 155 106 68 ± 5% 49 61 29 16 3
SMA SMN2+/−, Smn2B-Neo/2B-Neo 0.19 ± 0.02** 149 26 17 ± 3% 123 24 2 0 3
Motor Neuron Rescue SMA SMN2+/−, Smn2B-Neo/2B-Neo, Hb9-Cre+/− 0.63 ± 0.11 250 122 51 ± 2% 128 99 13 10 5
  • Table values are mean ± SEM **p ≤ 0.01 relative to control;

  • p ≤ 0.05 relative to severe inducible SMA. N = number of biological replicates. One-way ANOVA with Bonferroni's post hoc analysis.


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