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Article: Molecular and physiological diversity of cortical nonpyramidal cells.

Full Text (publisher's website) ; Article Metadata ; Article Data (extracted)
Cauli B; Audinat E; Lambolez B; Angulo MC; Ropert N; Tsuzuki K; Hestrin S; Rossier J
J. Neurosci., 1997


Table 1.

Physiological properties of four groups of necortical neurons

PYR (n = 29) FS (n = 34) RSNP (n = 48) IS (n = 10)1-a
f max(Hz) 20  ± 5 104  ± 25 42  ± 14 n.d.
PYR. < RSNP < FS
Early accommodation 66.2  ± 7.1% 15.3  ± 15.0% 46.6  ± 13.6% n.d.
(f initialf 200)/f initial FS < RSNP < PYR.
Late accommodation 7.4  ± 4.7% 6.0  ± 5.9% 10.1  ± 8.2% n.d.
(f 200f final)/f initial n.s.
t 1/2 early (msec) 15  ± 8 11  ± 8 29  ± 17 n.d.
PYR, FS. < RSNP
First spike duration (msec) 1.52  ± 0.29 0.59  ± 0.13 1.06  ± 0.28 0.95  ± 0.17
FS < RSNP, IS < PYR.
Second spike duration (msec) 2.68  ± 0.67 0.61  ± 0.13 1.35  ± 0.85 1.17  ± 0.35
FS < RSNP, IS < PYR.
Spike duration increase 75.6  ± 27.7% 3.7  ± 5.9% 21.4  ± 30.6% 23  ± 25%
FS < RSNP, IS < PYR.
First spike amplitude (mV) 92  ± 9 83  ± 8 88  ± 10 88  ± 10
n.s.
Second spike amplitude (mV) 61  ± 14 78  ± 7 79  ± 13 65  ± 13
PYR., IS < FS, RSNP
Spike amplitude reduction 34.1  ± 10.9% 6.4  ± 4.6% 13.1  ± 11.1% 26  ± 11%
FS < RSNP < PYR., IS
First AHP (mV) −1  ± 3 −24  ± 4 −15  ± 6 −10  ± 5
FS < RSNP, IS < PYR.
Second AHP (mV) −7  ± 3 −25  ± 4 −15  ± 5 −13  ± 4
FS < RSNP, IS < PYR.
Input resistance (MΩ) 245  ± 93 240  ± 106 389  ± 138 403  ± 122
PYR., FS < RSNP, IS
Resting potential (mV) −72  ± 4 −73  ± 8 −66  ± 7 −70  ± 7
n.s.
  • Values given are mean ± SD. n, Number of cells; n.d., not determined; n.s., no statistically significant difference. FS, Fast spiking cells; IS, irregular spiking cells; RSNP, regular spiking nonpyramidal cells; PYR, pyramidal cells. <, Significantly smaller with p = 0.01. Statistically significant differences were determined using the Mann-Whitney U test. Physiological parameters were measured as described in Materials and Methods. f initial, Frequency at the beginning of the discharge; f 200, frequency 200 msec after the beginning of the discharge; f final, frequency at the end of the current stimulation;f max, instantaneous discharge frequency measured at 600 msec during high intensity current injection (>200 pA).t 1/2 early, Time needed to reach 50% of the early accommodation.

  • F1-a  Accommodation parameters andf max could not be calculated for IS cells because of their bursting behavior. The five IS cells analyzed for the expression of CR, VIP, ChAT, GAD65, and GAD67 were not included in this table because they were recorded at 34°C.


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Inferred neuron-electrophysiology data values

Neuron Type Neuron Description Ephys Prop Extracted Value Standardized Value Content Source
Neocortex basket cell sensorimotor cortex fast spiking cell adaptation percent (1 – first/last ISI) 15.3 ± 15.0 (34) 15.3 (ratio) Data Table
Neocortex uncharacterized cell sensorimotor cortex regular spiking non-pyramidal cell adaptation percent (1 – first/last ISI) 46.6 ± 13.6 (48) 46.6 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 sensorimotor cortex pyramidal cell maximum firing rate (Hz) 20.0 ± 5.0 (29) 20.0 (Hz) Data Table
Neocortex basket cell sensorimotor cortex fast spiking cell maximum firing rate (Hz) 104.0 ± 25.0 (34) 104.0 (Hz) Data Table
Neocortex pyramidal cell layer 5-6 sensorimotor cortex pyramidal cell spike half-width (msec) 1.52 ± 0.29 (29) 1.52 (ms) Data Table
Neocortex basket cell sensorimotor cortex fast spiking cell spike half-width (msec) 0.59 ± 0.13 (34) 0.59 (ms) Data Table
Neocortex uncharacterized cell sensorimotor cortex regular spiking non-pyramidal cell spike half-width (msec) 1.06 ± 0.28 (48) 1.06 (ms) Data Table
Neocortex uncharacterized cell sensorimotor cortex irregular spiking cell spike half-width (msec) 0.95 ± 0.17 (10) 0.95 (ms) Data Table
Neocortex uncharacterized cell sensorimotor cortex regular spiking non-pyramidal cell maximum firing rate (Hz) 42.0 ± 14.0 (48) 42.0 (Hz) Data Table
Neocortex pyramidal cell layer 5-6 sensorimotor cortex pyramidal cell other 75.6 ± 27.7 (29) 75.6 (None) Data Table
Neocortex basket cell sensorimotor cortex fast spiking cell other 3.7 ± 5.9 (34) 3.7 (None) Data Table
Neocortex uncharacterized cell sensorimotor cortex regular spiking non-pyramidal cell other 21.4 ± 30.6 (48) 21.4 (None) Data Table
Neocortex uncharacterized cell sensorimotor cortex irregular spiking cell other 23.0 ± 25.0 (10) 23.0 (None) Data Table
Neocortex pyramidal cell layer 5-6 sensorimotor cortex pyramidal cell spike amplitude (mV) 92.0 ± 9.0 (29) 92.0 (mV) Data Table
Neocortex basket cell sensorimotor cortex fast spiking cell spike amplitude (mV) 83.0 ± 8.0 (34) 83.0 (mV) Data Table
Neocortex uncharacterized cell sensorimotor cortex regular spiking non-pyramidal cell spike amplitude (mV) 88.0 ± 10.0 (48) 88.0 (mV) Data Table
Neocortex uncharacterized cell sensorimotor cortex irregular spiking cell spike amplitude (mV) 88.0 ± 10.0 (10) 88.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 sensorimotor cortex pyramidal cell other 34.1 ± 10.9 (29) 34.1 (None) Data Table
Neocortex basket cell sensorimotor cortex fast spiking cell other 6.4 ± 4.6 (34) 6.4 (None) Data Table
Neocortex uncharacterized cell sensorimotor cortex regular spiking non-pyramidal cell other 13.1 ± 11.1 (48) 13.1 (None) Data Table
Neocortex uncharacterized cell sensorimotor cortex irregular spiking cell other 26.0 ± 11.0 (10) 26.0 (None) Data Table
Neocortex pyramidal cell layer 5-6 sensorimotor cortex pyramidal cell AHP amplitude (mV) -1.0 ± 3.0 (29) 1.0 (mV) Data Table
Neocortex basket cell sensorimotor cortex fast spiking cell AHP amplitude (mV) -24.0 ± 4.0 (34) 24.0 (mV) Data Table
Neocortex uncharacterized cell sensorimotor cortex regular spiking non-pyramidal cell AHP amplitude (mV) -15.0 ± 6.0 (48) 15.0 (mV) Data Table
Neocortex uncharacterized cell sensorimotor cortex irregular spiking cell AHP amplitude (mV) -10.0 ± 5.0 (10) 10.0 (mV) Data Table
Neocortex pyramidal cell layer 5-6 sensorimotor cortex pyramidal cell input resistance (MΩ) 245.0 ± 93.0 (29) 245.0 (MΩ) Data Table
Neocortex basket cell sensorimotor cortex fast spiking cell input resistance (MΩ) 240.0 ± 106.0 (34) 240.0 (MΩ) Data Table
Neocortex uncharacterized cell sensorimotor cortex regular spiking non-pyramidal cell input resistance (MΩ) 389.0 ± 138.0 (48) 389.0 (MΩ) Data Table
Neocortex uncharacterized cell sensorimotor cortex irregular spiking cell input resistance (MΩ) 403.0 ± 122.0 (10) 403.0 (MΩ) Data Table
Neocortex pyramidal cell layer 5-6 sensorimotor cortex pyramidal cell adaptation percent (1 – first/last ISI) 66.2 ± 7.1 (29) 66.2 (ratio) Data Table
Neocortex pyramidal cell layer 5-6 sensorimotor cortex pyramidal cell resting membrane potential (mV) -72.0 ± 4.0 (29) -72.0 (mV) Data Table
Neocortex basket cell sensorimotor cortex fast spiking cell resting membrane potential (mV) -73.0 ± 8.0 (34) -73.0 (mV) Data Table
Neocortex uncharacterized cell sensorimotor cortex regular spiking non-pyramidal cell resting membrane potential (mV) -66.0 ± 7.0 (48) -66.0 (mV) Data Table
Neocortex uncharacterized cell sensorimotor cortex irregular spiking cell resting membrane potential (mV) -70.0 ± 7.0 (10) -70.0 (mV) Data Table